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  • ABOUT US

18TH ANNUAL BIOTECH IN EUROPE FORUM
4TH-5TH OCTOBER 2018 @ CONGRESS CENTER BASEL, SWITZERLAND

PRESENTERS AT THE #Sachs_BEF FORUM

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​ABOUT 19th BEF

​Acesion Pharma ApS

Acesion Pharma ApS is a Danish biotech company founded in 2011 and based in Copenhagen. Acesion Pharma develops more efficacious and safe drugs for the treatment of atrial fibrillation (AF), the most common type of cardiac arrhyth- mia.

Existing  drug  therapies  generally  have  a  limited  effect  or  are  associated  with risk of serious adverse events, and there is therefore a considerable patient need for developing better and safer drugs. Inhibition of SK channels, an ion channel with relevance for regulating the heart rhythm, constitute a new and promising principle for the treatment of AF.
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Acesion Pharma aims to develop first-in-class SK channel inhibitors as a more efficacious  and  safe treatment  of  AF.  Equity  investors  in  Acesion  Pharma  are Novo A/S, Broadview Ventures, SEED Capital and Wellcome Trust. In 2013 Ace- sion Pharma received 27.9 million DKK (3.7 million EUR) as a Seeding Drug Dis- covery Award from the Wellcome Trust to fund the development of a novel drug for the acute treatment of AF.

http://www.acesionpharma.com/
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Addex Therapeutics Ltd. - [SWX: ADXN]

Addex Therapeutics is a biopharmaceutical company focused on the development of novel, orally available, small molecule allosteric modulators for neurological disorders. Allosteric modulators are an emerging class of small molecule drugs which have the potential to be more specific and confer significant therapeutic advantages over conventional "orthosteric" small molecule or biological drugs. Addex's allosteric modulator drug discovery platform targets receptors and other proteins that are recognized as essential for therapeutic intervention - the Addex pipeline was generated from this pioneering allosteric modulator drug discovery platform. Addex's lead drug candidate, dipraglurant (mGluR5 negative allosteric modulator or NAM) has successfully completed a Phase 2a POC in Parkinson's disease levodopa-induced dyskinesia (PD-LID), and is being prepared to enter registration trials for PD-LID. In parallel, dipraglurant's therapeutic use in dystonia is being investigated. Addex's second clinical program, ADX71149 (mGluR2 positive allosteric modulator or PAM) is being developed in collaboration with Janssen Pharmaceuticals, Inc for epilepsy. In addition, ADX71441 (GABAB receptor PAM) program was awarded a $5.3 million grant by the US National Institute on Drug Abuse (NIDA, a division of National Institutes of Health (NIH)) to support human studies in cocaine addiction and has been licensed to Indivior Plc. Discovery programs include mGluR4PAM, mGluR7NAM, TrkBPAM and mGluR3PAM.

https://www.addextherapeutics.com/
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Adocia - [​EPA: ADOC]

Adocia is a clinical-stage biotechnology company that specializes in the devel- opment of innovative formulations of already-approved therapeutic proteins. Adocia’s  portfolio  of  injectable  treatments  for diabetes,  featuring  five  clini- cal-stage products and five preclinical products, is among the largest and most differentiated of the industry. The proprietary BioChaperone® technological platform is designed to enhance the effectiveness and/or safety of therapeutic proteins while making them easier for patients to use. Adocia customizes BioChaperone to each protein for a given application in order to address specific patient needs.

CHEMOTHERAPEUTIC Adocia’s clinical pipeline includes four novel insulin for- mulations for the treatment of diabetes: two ultra-rapid formulations of insulin analogs (BioChaperone Lispro U100 and U200), a rapid-acting formulation of human insulin (HinsBet U100) and a combination of basal insulin glargine and rapid-acting insulin lispro (BioChaperone Combo). Additionally, an aqueous formulation of human glucagon (BioChaperone Human Glucagon) has recently entered clinical testing.

Adocia is also developing two combinations of insulin glargine with GLP-1s, (Bio- Chaperone  Glargine Dulaglutide  and  BioChaperone  Glargine  Liraglutide),  two combinations of insulin lispro with synergistic prandial hormones (BioChaper- one Lispro Pramlintide and BioChaperone Lispro Exenatide), and a concentrat- ed, rapid-acting formulation of human insulin (HinsBet U500), all of which are in preclinical development.
​
Adocia aims to deliver “Innovative medicine for everyone, everywhere.”

https://www.adocia.com/
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Affimed N.V. - [AFMD: US]

Affimed is a clinical-stage biopharmaceutical company focused on discovering and developing highly targeted cancer immunotherapies. Its product candidates are being developed in the field of immuno-oncology, which represents an innovative approach to cancer treatment that seeks to harness the body’s own immune defenses to fight tumor cells. The most potent cells of the human defense arsenal are types of white blood cells called Natural Killer cells, or NK-cells, and T-cells. Affimed’s proprietary, next-generation bispecific antibodies, termed TandAbs® because of their tandem antibody structure, are designed to direct and establish a bridge between either NK-cells or T-cells and cancer cells. Affimed’s TandAbs have the ability to bring NK-cells or T-cells into proximity and trigger a signal cascade that leads to the destruction of cancer cells. Due to their novel tetravalent architecture (which provides for four binding domains), the TandAbs bind to their targets with high affinity and have half-lives that allow intravenous administration. Affimed believes, based on the TandAbs mechanism of action and the preclinical and clinical data it has generated to date, that its product candidates may ultimately improve response rates, clinical outcomes and survival in cancer patients and could eventually become a cornerstone of modern targeted oncology care.

Affimed has focused its research and development efforts on three proprietary programs for which it retains global commercial rights. Because TandAbs bind with receptors that are known to be present on a number of types of cancer cells, each of Affimed’s TandAb product candidates could be developed for the treatment of several different cancers. Affimed intends to initially develop its two clinical stage product candidates in orphan or high-medical need indications, including development as a salvage therapy for patients who have relapsed after, or are refractory to, that is who do not respond to treatment with, standard therapies.

https://www.affimed.com/
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 Anagenesis Biotechnologies SAS

Anagenesis  Biotechnologies  is  preclinical-stage  stem  cell-based  company  focused  on  developing  novel  treatments  for  muscle  degenerative  diseases  and type 2 diabetes.

Anagenesis  Biotechnologies  secured  two  private  investments  from  the  AFM (French muscular dystrophy association) to develop applications in the skeletal muscle  therapeutic  area  and  from  Cap  Innov’Est.  Anagenesis  Biotechnologies aim is to become the world leader in muscle-related diseases.

http://anagenesis-biotech.com/
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​Anergis SA

Anergis is a private biopharmaceutical company dedicated to the discovery and development  of proprietary  ultra-fast  allergy  immunotherapy  products  based on its technology of contiguous overlapping peptides (“COP Allergy Vaccines”). Anergis raised over CHF 52 million to date from private and institutional investors, including BioMedInvest, Sunstone Capital, Renaissance PME and WJFS, Inc.

Allergies are the most prevalent and fastest growing chronic conditions in the industrialized world, affecting over 500 million people. The only curative treatment of allergies available today is the process of inducing tolerance to the allergen by allergy immunotherapy (AIT). Currently marketed AIT products require 3-5 years of treatment and expose patients to the risk of serious side effects such as anaphylactic reactions.

Anergis aims to develop the future of allergy treatment by providing novel treatments with long-lasting efficacy after a single 2-month treatment course (“ultra-fast” AIT treatment).

The proof-of-concept of ultra-fast AIT was demonstrated in clinical trials of AllerT (first generation COP allergy vaccine including aluminium hydroxide as adjuvant to the COPs): Anergis showed statistically significant efficacy vs placebo and demonstrated that the reduction in allergy symptoms persisted during the next annual pollen season and specific IgG4 antibodies remained significantly elevated after four seasons.

In  2018,  Anergis  initiated  a  research  program  on  the  second  generation  of COP Allergy Vaccines designed for enhanced efficacy and improved tolerability. This program includes a research collaboration with Mymetics Corporation (OTCQB:MYMX), a pioneer and leader in the research and development of virosome-based vaccines.

http://www.anergis.ch
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Anima Biotech, Inc.

Anima  Biotech  is  pioneering  Translation  Control  Therapeutics,  a  new  class  of drugs that control protein translation. Our novel platform enables for the first time  to  visualize  and  specifically  control the  synthesis  of  target  proteins.  By targeting the mechanisms that specifically regulate the process of mRNA translation,  we  discover  small  molecules  that  either  decrease  or  increase  a  target protein’s production, enabling a new strategy and new hope against hard and undruggable targets.

Our novel science is backed by 5 granted patents, 14 peer-reviewed publications and a network of 17 scientific collaborations.

We are strategically structured to partner with Pharma in multiple therapeutic areas. In July 2018 we signed a   collaboration agreement with Lilly for the use of our technology in the discovery and development of Translation Inhibitors of Several Protein Targets.

At the same time, we are moving our own fast pipeline growing forward. Our current  programs  are  in  Fibrosis  (inhibiting  the  synthesis  of  Collagen  type  I), Viral infections (Respiratory Syncytial Virus – interfering with viral protein synthesis), Oncology (C-Myc translation inhibitors) and Huntington’s disease (monitoring mutant Huntingtin translation pausing).

http://www.animabiotech.com/
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​Apeiron Biologics AG

APEIRON Biologics AG, based in Vienna, Austria, is a clinical stage biotech company developing innovative products in cancer immunotherapy. The company was founded by Professor Josef Penninger and became operational in 2006. Apeiron currently employs about 45 people and is led by a management team with strong background in the biotech industry and drug development, especially in immuno-oncology.

Apeiron’s impressive track record in R&D of innovative projects has been validated by several license deals with Pharmaceutical companies (GSK for APN01, Sanofi for APN411, EUSA Pharma for APN311) and importantly by the marketing authorization in the EU for APN311 in May 2017 (dinutuximab beta; Qarziba®). APN311 is a monoclonal antibody for immunotherapy of pediatric neuroblastoma, a rare and severe childhood cancer. 

https://www.apeiron-biologics.com/
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Aptose Biosciences, Inc. - [NASDAQ: APTO]

Aptose Biosciences is a science-driven biotechnology company advancing first-in-class agents to treat life-threatening cancers, such as acute myeloid leukemia (AML), high-risk myelodysplastic syndromes (MDS) and other hematologic malignancies. Based on insights into the genetic and epigenetic profiles of certain cancers and patient populations, Aptose is building a pipeline of novel oncology therapies directed at dysregulated processes and signaling pathways. Aptose is developing targeted medicines for precision treatment of these diseases, based on a patient’s specific gene expression signature. In the treatment of cancer, this strategy is intended to optimize efficacy and quality of life by minimizing the cytotoxic side effects associated with conventional therapies.

https://aptose.com/
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​ATRIVA Therapeutics GmbH

ATRIVA Therapeutics GmbH, an emerging antiviral biotech company, based in Tübingen, Germany, exploits the benefits of MEK-Inhibitors as powerful and broadly applicable antiviral drugs. MEK-Inhibitors, originally developed as cancer therapy, are blocking the intracellular kinase MEK, part of the Raf/MEK/ERK signaling pathway, which many RNA viruses need to replicate.

Eight experienced entrepreneurs and scientists founded ATRIVA in 2015 as a spin-off from the Universities Münster, Giessen and Tübingen. The lead project uses the scientific findings of three founders to develop a new class of treatment for severe influenza. ATRIVA already made substantial progress with the technology and the lead project as well as its project pipeline and has broadened its scope to other severe viral diseases including MERS, SARS (Coronavirus), Hantavirus (Bunyaviridae). Commonly, these viruses cause severe respiratory disease, often with fatal outcome, and no efficacious cure is yet available. MEK-Inhibitors are active against this variety of RNA viruses, as shown in several preclinical studies.

ATRIVA does not expect any resistance development, as the virus can- not reverse the blockade of the cellular signaling pathway. Relevant side effects within the intended antiviral use are unlikely, as 1) treatment dura- tion will not exceed 14 days, and 2) drug concentrations inhibiting viral replication are expected to be lower than those for anti-proliferative effects in tumor therapy, as shown in ATRIVA‘s extensive preclinical studies.

In essence, ATRIVA provides the technology for a completely novel anti-pathogen approach representing a paradigm change in therapy of severe respiratory infections.

https://www.atriva-therapeutics.com/
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​Atturos Ltd.

Atturos was founded in 2014 as a spin out company from University College Dublin with the ambition to develop and commercialise advanced diagnostics solutions to enable clinicians and patients make better decisions. Leveraging extensive expertise in mass spectrometry, proteomics and clinical research, Atturos is focussed on clinical and commercial translation of our lead product, the OCProDx test. This novel multimarker test is being developed to address a significant unmet need in the treatment of prostate cancer. Supported in part by a prestigious EU Horizon 2020 SME Instrument award the Atturos Leadership Team are working closely with multiple stakeholders across the clinical, scientific, and business community to drive the rapid growth and development of the company. The Atturos team are unashamedly ambitious in their plans for the company’s growth, however conscious that the result of the tests we are developing will influence the clinical decisions that change patients lives. We apply integrity to all we do in close association with patients and clinicians.

http://atturos.com/
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​Ayoxxa Biosystems GmbH

AYOXXA Biosystems GmbH is a venture-backed life science tools company driving advances that empower translational proteomics, setting sights on better diagnostics and therapeutics. Presently entering the commercial phase of growth, our company is an international and multidisciplinary team of scientists, technicians, engineers and business professionals working relentlessly to realize our vision of enabling success in translational proteomics.
​
Together, we have transformed an innovative technology exclusively licensed from the National University of Singapore in 2010, into a mature, groundbreaking protein analysis platform. Designed to deliver high-quality data on multiple proteins in the same small-volume sample, LUNARIS™ enables fully scalable quantitative validation of disease-relevantbiomarkers: from lab to clinic – from model to man – from data to insight.

https://www.ayoxxa.com/
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​BioElectron Technology Corporation

BioElectron is a platform biotechnology company, with expertise in the electron transfer (redox) chemical reactions that underpin oxidative stress and inflammation in all biological systems. We are using this expertise in redox biochemistry to develop first-in-class therapeutics for unmet medical needs. Our therapeutic candidates target a select set of enzymes, called oxidoreductases, with known biological significance.

Our initial clinical focus is on developing treatments for inherited mitochondrial diseases primarily affecting children, where there are unambiguous genetic alterations in key oxidoreductase systems. Mitochondrial diseases share a common feature: defects in DNA that encode for proteins critical to the proper handling of electrons. The process of regulating the flow of electrons is known as redox control, and it is essential to the generation and regulation of energy in living systems. Thus, mitochondrial diseases are diseases of redox control. These diseases commonly result in severe neurological impairment and death at an early age. At present, there are no FDA- or EMA-approved treatments.

Through the reverse-engineering of mitochondrial diseases, BioElectron has been able to identify a number of initial drug targets, which has led to the development of drug candidates aimed at treating children with mitochondrial diseases. These drugs are in active clinical development. Our current lead drug, EPI-743, uniquely targets 15-lipoxygenase—a key enzyme involved in the regulation of oxidative stress, inflammation and programmed cell death (also known as ferroptosis), biological processes that are significant in the pathology of mitochondrial and other diseases.

We also possess a rich pipeline of other first-in-class targets, novel drug candidates, and paired diagnostics for a wide array of conditions; e.g. Parkinson’s disease, ALS, diabetes, autism and cancer. These conditions share a common biochemical basis—defects in electron-based (redox) cellular communication systems.

​http://www.bioelectron.com/
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Biosceptre (UK) Ltd.

Biosceptre is a UK headquartered biotech developing next-generation cancer therapeutics utilising its proprietary target, nfP2X7. Biosceptre has an experienced team of scientists and executives based in state of the art facilities at the Babraham Research Campus, Cambridge UK and at Sydney Australia.

Biosceptre has multiple clinical programs designed to exploit nfP2X7 via a range of modalities including systemic antibodies, vaccines and topical therapeutics. A’s comprehensive global IP portfolio covers broadly both the target itself and multiple drug modalities, as well as multiple candidates designed to exploit nfP2X7.

http://www.biosceptre.com/
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Boston Pharmaceuticals, Inc.

Boston Pharmaceuticals acquires and transforms innovative molecules into differentiated medicines that improve patients’ lives. We have rapidly built a portfolio of high-value candidates across multiple therapeutic areas and are actively seeking additional programs for our diverse pipeline.

https://www.bostonpharmaceuticals.com/
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​Caelus Health

Caelus Health is an Amsterdam-based biotech company developing an entirely new class of Microbiome Therapeutics for the reduction of insulin resistance and prevention of Type 2 Diabetes (T2DM) in people with metabolic syndrome.

The company is dedicated to the commercialisation of functional food and pharmabiotic products for the prevention and early treatment of cardio metabolic diseases – based on the strong correlation between the intestinal microbiome and health.

Caelus Health builds on the experience of leading scientists in this field and is one of the very few companies that can effectively capture the value of Microbiome Therapeutics through their solid preclinical and early-stage clinical development approaches.

http://caelushealth.com
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Cantargia AB - [​CANTA: SS]

Cantargia specialises in antibody-based cancer treatment. CAN04, the company's patented antibody treatment, has a dual mechanism of action. CAN04 fights cancer by activating the immune system and blocking signals that lead to tumour growth. Treatment with CAN04 has the potential to become an important part of modern immuno-oncology.

Potential for several cancer diseases
Cantargia is developing antibody-based treatments specifically targeting the molecule IL1RAP with a potential to treat a number of different cancers. The lead candidate, CAN04, is initially focused on non-small cell lung cancer (NSCLC) and pancreatic cancer and clinical trials started in 2017. The aim is to develop a new drug with the potential to become an important part of future cancer treatment.

Our product candidate CAN04
CAN04 is designed to block the cancer cell's signalling via the interleukin-1 system. Thereby counteracting the tumour inflammation that facilitates growth and protection of the tumour. CAN04 is also designed to stimulate the body's immune system to eliminate cancer cells directly.

Project CANxx
Cantargia has started development of a new antibody against IL1RAP which will also be subject for patent protection. The new antibody is being designed for treatment of autoimmune and inflammatory diseases, with the aim to have a product candidate selected during 2019.

Background
Cantargia AB was founded in 2009/2010 based on a discovery made by Professor Thoas Fioretos and Dr Marcus Järås at Lund University. Their research showed that leukaemic stem cells express a protein, IL1RAP, on the cell surface which is not expressed to the same extent on normal stem cells. Cantargia's research has since then shown that IL1RAP is also expressed in a range of solid tumour cancers.

IL1RAP is important for the cancer cells' ability to create a favourable environment for proliferation and expansion and antibodies targeting IL1RAP could potentially be used to treat several different forms of cancer, but also autoimmune and inflammatory diseases.

http://cantargia.com/
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Clinuvel Pharmaceuticals Ltd.

CLINUVEL  PHARMACEUTICALS  LTD  is  a  global  biopharmaceutical  company focused on developing and delivering treatments for patients with a range of severe  genetic  and  skin  disorders.  As  pioneers in  photomedicine  and  understanding the interaction of light and human biology, CLINUVEL’s research and development  has  led  to  innovative  treatments  for  patient  populations  with  a clinical  need for photoprotection  and  repigmentation.  These  patient  groups range in size from 5,000 to 45 million worldwide.

CLINUVEL’s lead compound, SCENESSE® (afamelanotide 16mg), was approved by the European Commission in 2014 for the prevention of phototoxicity (anaphylactoid reactions and burns) in adult patients with the rare genetic disorder erythropoietic protoporphyria (EPP).

As  the  first  ever  photoprotective  drug,  SCENESSE®  activates  eumelanin,  the dark pigment in skin. Eumelanin is capable of selective light absorption, including at the wavelengths of light which excite protoporphyrin IX, the compound which causes phototoxic reactions in patients diagnosed with EPP, a disorder which causes absolute intolerance to light (blue and green spectrum).
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Headquartered  in  Melbourne,  Australia,  CLINUVEL  has  operations  in  Europe, Switzerland, the US and Singapore.

http://www.clinuvel.com/
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​Crescendo Biologics Ltd.

Crescendo Biologics is a biopharmaceutical company developing potent, multi-functional Humabody® therapeutics in Oncology with a proprietary pipeline focus on CB307, a unique targeted T-cell engager.
Humabody® therapeutics are based on our robust, proprietary, transgenic platform generating fully human VH domain building blocks (Humabody® VH) with superior biophysical properties. Using our in-house formatting and drug development expertise, we can rapidly assemble fully human VH building blocks into an almost limitless array of optimally configured mono- and multi-functional Humabody® therapeutics capable of engaging targets in ways that are fundamentally different from IgG.

This modular approach coupled with Humabodies’ superior biodistribution lacks the constraints of traditional mAbs and enables a radical rethink of the design and assembly of multi-functional molecules to deliver enhanced therapeutic benefit through novel modes of action.

​https://www.crescendobiologics.com
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​Dyadic International, Inc.

Dyadic International, Inc. is a global biotechnology company based in Jupiter, Florida with a foreign subsidiary, Dyadic Nederland, BV, which maintains a small satellite office in Wageningen, the Netherlands.  Over the past two decades, the Company has developed a method for producing commercial quantities of enzymes and other proteins required for the production of industrial enzymes and has successfully licensed this technology to third parties such as Abengoa Bioenergy, BASF, Codexis and others.  This technology is based on the Myceliophthora thermophila fungus, which the Company named C1.  The C1 technology is a robust and versatile fungal expression system for gene discovery, development, expression and production of enzymes and other proteins.

​https://www.dyadic.com/
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Emerald Health Sciences, Inc.

The vision of Emerald Health Sciences (EHS) is to enhance health and well-being through diverse investments that advance the development of cannabis in pharmaceutical, botanical and bioceutical applications.

EHS is realizing this vision by supporting the application of scientific rigor to all the products researched and developed through its investments in compliance with all international and federal regulations.

The rapid growth of EHS is testament to the ability of its leadership to create value by leveraging long-standing relationships and experience to attract expertise and accumulate assets that support its vision.

http://emerald.life/
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Exogenus Therapeutics, S.A.

The company was founded by two researchers, Joana Simões Correia and Ricardo Neves and one manager, Luísa Marques. The project that led to the creation of the company (Nanoinspire) participated in COHiTEC 2014 program and is the result of the research developed in collaboration between the Centre for Neurosciences  and  Cellular  Biology  of  Coimbra  University,  Crioestaminal  SA, and Biocant. Founded in June 2015, the company has so far secured €1M fund- ing, of which €900K from venture capital firms, and in excess of €600K from a Portugal 2020 R&D grant.

Exo-T received the Young Entrepreneur Award by ANJE in 2015, and the Everis Award  in  2016.  In  the  same  year,  the  company  obtained  the  SME  Instrument Phase 1 support from the European Commission, and in 2017 the company was a finalist of the Alira Health - EWMA (European Wound Management Association) Award, recognizing Exo-T as one of the top 5 most Innovative Companies worldwide in wound care.

http://www.exogenus-t.com/
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F-star Biotechnology Ltd.

F-star  is  a  clinical-stage  biopharmaceutical  company  committed  to  delivering life-changing treatments to cancer patients. Through our highly efficient Modular  Antibody  Technology™  platform,  we  are  building  and  progressing  an  extensive immuno-oncology pipeline of mAb²™, a novel class of disruptive bispecific antibodies designed to unlock new biology which cannot be achieved by combining  monospecific  drugs.  F-star’s  technological  expertise  and  scientific approach have been validated through strategic partnerships with leaders in the pharma and biotech industries.

http://www.f-star.com/
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GamaMabs Pharma SA

GamaMabs Pharma is a clinical-stage immuno-oncology company developing optimized therapeutic antibodies for the treatment of cancer.

GamaMabs’ lead project is the monoclonal antibody (mAb) GM102 which targets Anti-Müllerian Human Receptor II (AMHRII), an unaddressed specific target in cancer.

The company develops low-fucose EMABling® antibodies with increased tumor cell killing properties through the activation of immune system cells. GamaMabs has a licensing agreement with MedImmune (USA) to develop an Antibody Drug Conjugate targeting cancer.

http://www.gamamabs.com/
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GeNeuro SA - [​EPA: GNRO]

GeNeuro is a clinical stage pharmaceutical company developing a new approach to the treatment of autoimmune and neurodegenerative diseases, including multiple sclerosis (MS) and Type 1 Diabetes (T1D) associated with pathogenic proteins expressed by human endogenous retroviruses (HERV), viral genes that account for 8% of human DNA.​

http://www.geneuro.com/
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Herantis Pharma Plc.

Millions of people all over the world suffer from diseases, for which there is no known treatment. At the same time, thousands of skilled scientists are working on early research projects, which might one day provide novel therapies for the people in need.

Herantis Pharma Plc is an innovative drug development company focused on regenerative medicine for breakthrough in unmet clinical needs. Our first-in-class assets are based on globally leading scientific research in their fields: CDNF for disease modification in neurodegenerative diseases, primarily Parkinson’s and ALS; and Lymfactin® for breast cancer associated lymphedema, with potential also in other lymphedemas.

Herantis’ shares are listed on NASDAQ OMX Helsinki First North Finland.

http://herantis.com/
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​IGEM Therapeutics Ltd.

IGEM Therapeutics is a UK Immuno-Oncology company developing novel IgE antibodies to treat cancer. IgE has evolved to kill tissue-dwelling multicellular parasites endowing it with several key features that make it ideal for the treatment of solid tumours which also mostly reside in tissue. The epsilon constant region of IgE binds very tightly to its cognate receptor (FcεRI) on the surface of immune effector cells including macrophages, monocytes, basophils and eosinophils. This interaction is up to 10,000 fold greater than the gamma chain of IgG has for its equivalent receptor and this results in the majority of IgE molecules being permanently attached to the surface of immune effector cells. The latter are therefore primed and ready to destroy cells expressing the antigen recognised by the IgE. As a result, IgE is able to permeate tissues more effectively than IgG and stimulate significantly greater levels of both ADCP (antibody-dependent cell-mediated phagocytosis) and ADCC (antibody-dependent cell-mediated cytotoxicity), the two main mechanisms by which immune effector cells can kill tumour cells. IgE also has a significantly longer tissue half life than IgG (2 weeks versus 2 – 3 days) which also suits it for a role in the destruction of solid tumours.

The company’s lead programme targets the folate receptor alpha (FR alpha) and an anti-FR alpha IgE antibody is currently in a phase 1/2a trial to treat ovarian cancer. This is the world’s first IgE therapeutic to enter the clinic.

IGEM is also developing a novel antibody platform technology based on protein and glyco-engineering of the epsilon constant region.

https://igemtherapeutics.com
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​ILTOO Pharma

ILTOO Pharma is a clinical-stage biotechnology company dedicated to the development of biotherapies that have the ability to balance the immune system and revolutionize the treatment of autoimmune and inflammatory disorders (ADs). Based on a deep expertise in translational research and clinical immunology, ILTOO Pharma is pioneering the field of regulatory T cells (Tregs)-mediated immunotherapies.

ILTOO Pharma lead product, ILT-101, is the world most advanced IL-2-based therapies. ILTOO’s vision is that, along with corticosteroids and anti-TNFs antibodies, IL2-mediated immunotherapy will become the next-generation standard of care for treating ADs. Systemic lupus erythematosus (SLE) and recently diagnosed type-1 diabetes (T1D) have been selected as top priority indications. By targeting an immunological imbalance which is the common root cause of ADs, ILT-101 has the potential to bring an enhanced therapeutic benefit to a wide spectrum of patients affected by ADs.

http://www.iltoopharma.com/
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​Imcyse SA

Imcyse is pioneering the development of a new class of active, specific immunotherapeutics: ImotopesTM. Imcyse’s new technology platform is based on the discovery of modified synthetic peptides to block the immune processes causing immune-mediated diseases. Imcyse’s ImotopesTM  offer the possibility to cure severe chronic diseases for which there is no satisfactory therapeutic alternative. The technology can also prevent the immunogenic responses that weaken the efficiency of chronic therapies.


Our vision is to become a major player in active specific immunotherapy for the curative treatment of autoimmune and allergic diseases.

http://www.imcyse.com/en

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Immunicum AB - [STO: IMMU]

Immunicum  is  establishing  a  unique  immuno-oncology  approach  through  the development of allogeneic, off-the-shelf cell-based therapies. Our goal is to improve survival outcomes and quality of life by priming the patient’s own immune system  to  fight  cancer.  The  company’s  lead  product ilixadencel,  consisting  of pro-inflammatory allogeneic dendritic cells, has the potential to become a backbone component of modern cancer combination treatments in a variety of solid tumor indications. Founded and based in Sweden, Immunicum is publicly traded on the Nasdaq Stockholm.

http://immunicum.se/
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Immunomic Therapeutics, Inc.

Immunomic Therapeutics, Inc. (ITI) is a privately-held clinical stage biotechnology company pioneering the study of nucleic acid immunotherapy platforms. These investigational technologies have the potential to alter how we use immunotherapy for cancer, allergies and animal health. On the heels of two landmark deals in 2015, including an exclusive worldwide license with Astellas Pharma Inc. to explore  the  use  of  LAMP-Vax™  for  use  in  the  prevention  and  treatment  of allergic diseases which resulted in over $315M in licensing revenue that year, the company has now focused on the application of its UNITE™ platform in oncology.

https://www.immunomix.com/
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Inotrem S.A. 

INOTREM SA is a biopharmaceutical company discovering and developing first-in-class immunotherapies for the treatment of inflammatory diseases. The Company is developing a new concept of immunomodulation targeting the amplification loops of the innate immune response with an initial focus on septic shock. With a high mortality rate, a growing incidence and a lack of specific mechanistically targeted treatment, severe sepsis and septic shock is a major public health problem in urgent need of a solution.

The INOTREM scientists and co-founders are international leaders in TREM-1 biology (Triggering Receptor Expressed on Myeloid cells-1) and authors of numerous studies demonstrating the role of TREM-1 in severe sepsis as well as myocardial infarction.

https://www.inotrem.com/
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​InterAx Biotech AG

InterAx is uniquely positioned to assist drug candidate design and selection by integrating bioanalytical and computational pharmacology in partnership projects with Biotech and Pharma companies. InterAx applies mathematical models and simulations to in house-derived bioanalytical data in order to address the complexity of drug-induced cellular signaling mechanisms. Our goal is to close the gap between laboratory experiments and in vivo studies by streamlining the critical processes of drug candidate design and selection, thereby significantly reducing the risks, costs and duration of drug discovery and development of new drugs.

http://www.interaxbiotech.com
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ISA Pharmaceuticals B.V.

ISA is a late stage clinical company based in Leiden, The  Netherlands. Its lead product is entering phase 3 clinical trials. 
In December 2017, ISA entered into a strategic partnership with Regeneron Pharmaceuticals for is lead product ISA101 for treatment of HPV-16 induced diseases. Herewith, ISA has established a clear path to market for it lead product. Under the partnership, ISA101 is currently entering  randomized controlled trials in head- and neck (phase 2) and cervical cancer (phase 3). These trials are aimed at securing first approvals for ISA101  in combination with cemiplimab (aPD-1). First data from these trials are expected in H2 2020. Under the agreement, Regeneron made  significant up-front  financial commitments  and ISA is eligble for substantial near term revenues.

ISA’s product pipeline further consists of several  proprietary compounds in multiple orphan indications with fast path to market. As next step, ISA aims to establish clinical PoC for the two next products in its pipeline. In addition, ISA has an exciting pre-clinical pipeline targeting cancer and chronic viral infections.

ISA’s development platform is based on its proprietary SLP® (synthetic long peptide) and AMPLIVANT® technologies and its next generation manufacturing capabilities. These platforms are broadly applicable and suitable for a multitude of targets and product opportunities.  

The company has established its development platform based on insight into the exact mechanism of action and the immunopharmacology of its immunotherapeutics. Various clinical trials up to completion of Phase II have demonstrated the safety, tolerability and clinical efficacy of SLP® compounds, thereby providing proof-of-concept.

http://www.isa-pharma.com/
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Karyopharm Therapeutics, Inc. - [NASDAQ: KPTI]

Karyopharm  Therapeutics  Inc.  is  a  clinical-stage  pharmaceutical  company  focused on discovery, development and commercialization of novel first-in-class drugs directed against nuclear transport and related targets for the treatment of cancer and other major diseases.

Karyopharm’s  primary  focus  is  on  developing  novel,  small  molecule  Selective Inhibitor of Nuclear Export, or SINE, compounds that inhibit the nuclear export protein  XPO1.  Their  lead  oral  SINE compound  selinexor  is  being  evaluated  in multiple late stage clinical trials in patients with hematologic and solid tumor malignancies. Selinexor has been granted Orphan Drug Designation in multiple myeloma and Fast Track designation for the patient population evaluated in the STORM study.

Karyopharm  has  submitted  a  New  Drug  Application  (NDA)  to the U.S. Food and Drug Administration (FDA), with a request for accelerated approval for oral selinexor as a new treatment for patients with penta-refractory multiple myeloma. The Company also plans to submit a Marketing Authorization Application (MAA) to the European Medicines Agency (EMA) in early 2019 with a request for conditional approval.

In addition to selinexor, Karyopharm is advancing a pipeline of novel, oral drug candidates,  including eltanexor  as  a  treatment  for  colorectal  cancer,  myelodysplastic syndrome, and castrate-resistant prostate cancer, KPT-9274, a dual PAK4/NAMPT inhibitor for the treatment of patients with advanced solid malignancies or non-Hodgkin’s lymphoma, and verdinexor as an anti-viral agent, as well as a potential treatment for cancer in companion animals.

Karyopharm was founded by Dr. Sharon Shacham and is headquartered in New- ton, MA.

​https://www.karyopharm.com/
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Keapstone Therapeutics Ltd.

Keapstone Therapeutics is a single asset biotech developing drugs that target the Nrf2 signalling pathway (KEAP1 inhibitors) for two devastating conditions – Parkinson’s and Motor Neuron Disease (MND) – which together affect more than 130,000 people in the UK. Keapstone was co-founded in February 2017 by the University of Sheffield, Parkinson’s UK and scientists Richard Mead and Pamela Shaw of the Sheffield Institute for Translational Neuroscience (SITraN).  The company has exclusive rights to develop intellectual property related to a novel chemical series identified at Sheffield. The company combines world-leading research from the university with funding and expertise from Parkinson’s UK and consultants and discovery partners with extensive drug development expertise.

https://www.keapstone.com
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​LIfT BioSciences Ltd.

LIfT BioSciences is a socially-minded Biotech start-up developing The World's First Cell Bank of Cancer Killing Granulocytes (a type of white blood cell).  The Cell Bank will enable us to provide a range of potentially life-saving immuno-oncology cell therapies for different solid tumour types. Our innate immunity platform is known as Neutrophil only Leukocyte Infusion Therapy (N-LIfT), a first-in-class patented cell therapy. N-LIfT is produced ex-vivo and benefits from being more scalable with potentially better and more consistent efficacy and safety than other forms of leukocyte infusion.

LIfT BioSciences Ltd was set-up with Prof Zhen Cui of Wake Forest University, a leading pioneer in LIFT, following his discovery of a cancer resistant (SR/CR) mouse that proved to have transferable innate immunity. 

The first targeted indication is pancreatic cancer (pancreatic ductal adenocarcinoma – PDAC), one of the types of cancer with the highest unmet medical need. CRUK report that just 3% of Patients Diagnosed with PDAC survive 5 years. PDAC is classified as an orphan disease by European Medicines Agency (EMA) which will facilitate our market access. The EMA has classified N-LIfT as an Advanced Therapeutic Medicinal Product (ATMP), which sets us up for  accelerated approval (early access scheme) and enhanced proprietary protection (market and data exclusivity), subject to trial results.

We are currently completing pre-clinical work before running our first in-human clinical trial. The aim is to demonstrate remission in high unmet need solid tumours by 2021, including Pancreatic Cancer.  

Due to the sensitivity of our work and the IP required to successfully bring this therapy to market we are unable to disclose more at present. If you would like to find out more, or if you would be interested in investing please Contact Us.

https://www.liftbiosciences.com
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​Medherant Limited

Medherant  was  founded  by  Professor  David  Haddleton  and  the  University  of Warwick to develop and commercialise novel technologies for delivery of drugs via  the  skin  using  their  world-leading expertise  in  bioadhesives  and  polymer chemistry. The Company is based on the University of Warwick Science Park in Coventry (UK). Medherant has received investment from Mercia Fund Management and others.

Delivery of drugs using patches that are applied to the skin provides better control of the dose than with gels, ointments and creams. However, the currently available technologies limit the types of drugs that can be used and the quantities that can be loaded into the patch. Medherant’s TEPI Patch® is formulated with a novel polymer adhesive which has been exclusively licensed from Bostik. The drug to be delivered is mixed with the adhesive to form a thin, flexible, single layer patch.

One  of  the  key  advantages  of  the  TEPI  Patch®  technology  is  that  a  greater quantity of drug can be blended with the adhesive. This enables lower potency drugs to be formulated as a patch and provides the opportunity to increase the dose of drugs already administered via a patch or reduce patch size. The TEPI Patch® also provides a better experience for the user as it does not leave a residue around the patch – referred to as ‘cold flow’ – and has excellent adhesion whilst still being easy and painless to remove.

Medherant is developing its own TEPI Patch® products and working with third parties to assess the suitability of the technology for their drugs. The Company expects to earn revenues from licensing products that it has developed to pharmaceutical companies and through collaborative development projects leading to potential technology licences.

https://www.medherant.co.uk/
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​Memo Therapeutics AG

Memo Therapeutics AG (MEMO) is an innovator in the field of antibody discovery and immune repertoire analysis. Its MemoMAB™ platform creates a recombinant in vitro copy of an individual’s B cell / antibody repertoire, which is then banked as a library. The resulting unique, large and relevant antibody libraries represent the individual’s immune repertoire and are expected to contain an unprecedented number of relevant and rare antibodies. This leads to entirely new possibilities in immune repertoire analysis and antibody discovery. The business strategy of MEMO is the discovery of therapeutic antibody candidates and target discovery for antibody and vaccine development.

​MemoMAB™ is deployed in proprietary antibody lead discovery programs and is made available in collaborations.

​http://memomab.com/
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metaLinear Ltd.

metaLinear offers a fast track to highly validated drug targets and lead compounds, some of which will be available for licensing. Our focus is on antibiotics/antibiotic resistance.

Our proven technology manipulates proteins inside living cells, reaching the >90% of biology inaccessible to siRNA or CAS/Crispr.

metaLinear’s technology also overcomes multiple bottlenecks in traditional drug discovery workflows, including POM, Z factor determination, SAR and cross-species toxicity.

metaLinear was established in November 2016 and began operating from the Biohub at Alderley Park in Cheshire from March 2017. Operated by life science incubation specialist, The BioCity Group, Biohub supports the creation and growth of successful life science companies including Redx, Blueberry Therapeutics and the Anti-Microbial Research Centre.

http://www.metalinear.co.uk/
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Metys Pharmaceuticals AG

Metys Pharmaceuticals is developing dimiracetam for the prevention of chemotherapy-induced painful peripheral neuropathy. In the US alone, in a single year, more than 400'000 patients suffer from the neuropathy caused by their life-saving cancer treatment. No drug has been approved to prevent or treat this condition. Dimiracetam is an orally active, small molecule with more than 200 patients' safety and tolerability data; dimiracetam is highly effective in preventing and treating chemotherapy-induced neuropathy in rodents. Metys Pharmaceuticals is preparing the first dedicated efficacy study of dimiracetam in this indication.

http://www.metys-pharma.ch/
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MGC Pharma Pty. - [ASX: MXC]

MGC  Pharmaceuticals  is  a  publicly  traded  (ASX:MXC)  BioPharma  company focused on the development and formulation of indication specific Phytocannabinoid Medications. MGC Pharma has created a seamless, highly-supervised supply chain, for developing Phytocannabinoid medications from seed to sale, with global operations providing proprietary Phytocannabinoid formulations to researchers, doctors and patients worldwide.
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https://mgcpharma.com.au/
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​Mymetics SA - [OTCQB:MYMX]

Our vaccines are designed to induce protection against early transmission and infection, focusing both on the mucosal immune response as a first-line defense and the systemic humoral (blood) immune response, which, for some pathogens, may be essential for the development of an effective prophylactic vaccine. Our unique approach has resulted in the development of a rich pipeline of vaccine candidates for HIV-1/AIDS, intra nasal Influenza, Malaria, Chikungunya and the Respiratory Syncytial Virus (RSV) vaccine. Our delivery platform is being validated through partnership with leading pharmaceutical or research organisations, including Sanofi, PATH-MVI and the Bill and Melinda Gates Foundation. Mymetics Corporation (OTCQB: MYMX) is a Swiss based biotechnology company, with a Research Lab in the Netherlands. The company is registered in the US and trades on the OTCQB.

https://www.mymetics.com/
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​Nanobiotix Corp. - [NANO: FP]

​Nanobiotix is a late stage clinical company pioneering nanomedicine for more than a decade. We intend to significantly change the outcomes for cancer patients following a different path than other Pharma or Biotech companies: a new way to treat patients thanks to nanophysics at the heart of the cell.

Nanobiotix is a spin-off from the State University of New York (SUNY), Buffalo and was incorporated in 2003. Nanobiotix is listed on the regulated market of Euronext Paris on 29 October 2012 (ISIN: FR0011341205, Euronext ticker: NANO, Bloomberg: NANO: FP).

Nanobiotix operates worldwide from the headquarters based in Paris, France and affiliate office in Cambridge, MA, USA. Nanobiotix has partnered with PharmaEngine for clinical development and commercialization of NBTXR3 in Asia.

The company’s first technology, NanoXray, is based on proprietary technologies and patents. The goal of our products is to help millions of patients receiving radiotherapy by magnifying the effect of radiotherapy within tumor cells, without increasing the dose to surrounding healthy tissues.

We develop first-in-class products with the aim to provide a maximum benefit with a minimum change in the medical practice in order to limit the hurdle of healthcare cost.

The most advanced product, NBTXR3, is in registration clinical phase and the Company has filed in August 2016 for market approval (CE Marking) in Europe.

http://www.nanobiotix.com
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NovaGo Therapeutics AG

NovaGo Therapeutics is a biotech start-up company dedicated to the development of human antibody therapeutics targeting cerebral stroke and spinal cord injury to stimulate nerve repair and regeneration. A strategic partnership with Neurimmune provides access to a unique class of human-derived antibodies with exceptional therapeutic properties generated through their Reverse Translational Medicine™ (RTM™) technology platform.

The founding and management team has a proven track record in research and drug development. Existing collaborations and networks with partners in industry, academia, and the medical community leverage the advancement of our programs.

http://www.novagotherapeutics.com/
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​Novaremed AG

Novaremed  is  a  clinical-stage  Swiss  biopharmaceutical  company  focused  on the development of NRD.E1, an orally active New Chemical Entity (NCE) for the treatment of Neuropathic Pain.

Novaremed was founded in Israel in 2008, where development work was done up to a successful Phase IIa Proof of Concept (PoC) study in Diabetic Neuropathic Pain (DNP).

In 2017, Novaremed moved from Israel to Basel, Switzerland, which is one of the most important biotech and pharma clusters in Europe. This relocation allowed the company to gain access to experienced clinical development staff and services and investor capital.
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Novaremed is currently preparing for a global Phase IIb study in DNP.

https://www.novaremed.com
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OncoVITA SAS

​Founded in 2015, OncoVITA is an early-stage biotech company developing a disruptive virus technology to treat multiple types of cancer. This proprietary technology is derived from the safe and highly immunogenic measles vaccine virus, which has clinically proven oncolytic potential. Over 15 years of R&D has allowed OncoVITA to build upon the measles vaccine virus and to bring forward a new virus with even stronger oncolytic properties: MVdeltaC. This candidate proved highly efficient in a panel of pre-clinical studies in vitro and in vivo. Not only does the virus specifically target and destroy cancer cells, but it also has the potential to elicit a strong and long-lasting anti-tumour immune response. Our initial clinical focus is the ovarian cancer resistant to chemotherapy. This technology, developed at the Institut Pasteur in Paris, has intellectual property protection up to 2033 with possible extensions that OncoVITA’s IP portfolio is building upon.

https://www.oncovita.fr/
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Oryzon Genomics S.A. - [​BME: ORY]

​Oryzon is a public clinical stage biopharmaceutical company and the European leader in the development of epigenetics-based therapeutics. From its founding in 2000 through 2008, the company focused its efforts in growing a genomics diagnostics business model, providing genomics services to the pharmaceutical industry in Europe. In 2008, with the acquisition of Crystax Pharmaceuticals, we started our drug discovery programs in oncology and neurodegenerative diseases. Our business model is to develop our proprietary drug candidates through clinical phase II, at which point it is decided on a case-by-case basis to either keep the development in-house or to partner or outlicense the compound for late stage development and commercialization. Oryzon is listed on the Spanish Stock Exchange since December 2015 (ORY, ISIN Code: ES0167733015). In the period 2015-2016, the company raised €32M, with additional €18.2M raised from blue chip investors in the US and Europe in March 2017.

With two compounds in clinical trials, ORY-1001, a highly potent and selective LSD1 inhibitor that has been granted orphan-drug status by EMA, in Phase I/IIA in oncology, and ORY-2001, a dual LSD1/MAO-B inhibitor for the treatment of multiple sclerosis, Alzheimer’s disease and other neurodegenerative diseases, in Phase IIA, as well as another compound in preclinical development, ORY-3001, a selective LSD1 inhibitor for the treatment of non-oncological diseases, and additional programs in other cancer indications, the company has a broad and growing portfolio. From 2014 to 2017 the company had a collaboration with Roche relating to our lead oncology program and received +$23M. This asset is now being developed by Oryzon. The company has also obtained competitive US and European grants in the amount of €8M to support the development of ORY-2001 since the start of our CNS research.

The company has a seasoned executive management with vast experience in the industry.

https://www.oryzon.com/
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OSE Immunotherapeutics - [EPA:OSE]

OSE Immunotherapeutics SA (ISIN: FR0012127173; Mnemo: OSE) is a biotechnology company focused on the development of innovative immunotherapies for immune activation and regulation in the fields of immuno-oncology and autoimmune diseases.

The  company  utilizes  several  scientific  and  technological  approaches  including neoepitopes and agonist/antagonist monoclonal antibodies, all ideally positioned to fight cancer and autoimmune diseases. Its first-in-class pipeline offers a diversified risk profile, ranging from registrational to clinical stage to R&D. These new generation products are optimized to better target key receptors of the immune response’s activation or regulation, thus allowing for longer therapeutic effects.

The company relies upon its international and complementary team of experts involved in the research and optimisation of drug candidates, pharmaceutical development and drug registration to develop the next wave of novel immuno- therapies.

OSE Immunotherapeutics is partnership focused to ensure, through premier international  pharma, clinical  and  academic  collaborations,  the  fastest  possible delivery of its product candidates to patients in need.

Based  in  Nantes  (Head  Office)  and  Paris,  the  company  is  listed  on  Euronext Paris.

http://ose-immuno.com/en/
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Oxurion NV - [EPA:OXUR]

Oxurion is a biopharmaceutical company developing treatments to preserve vision for patients with diseases affecting the back of the eye. It has engineered a diverse portfolio of disease-modifying drug candidates, including treatments for diabetic eye disease, a leading cause of blindness in people of working age worldwide.

Oxurion owns the global rights to Jetrea (ocriplasmin), the only pharmacological vitreolysis drug approved for the treatment of symptomatic vitreomacular adhesion (in the U.S.) and vitreomacular traction (outside the U.S.).

Oxurion is headquartered in Leuven, Belgium, and is listed on Euronext Brussels under the symbol OXUR.

https://www.oxurion.com
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PBimmunomics

We are currently developing diagnostic tests and precision drugs based on immunoprofiles discovered with MVA.

With MVA, we have identified profiles for several cancers, cardiovascular diseases, autoimmune disease and numerous others.

In addition to developing diagnostics and therapeutics, we are searching for partners interested in applying MVA to further discover the immune systems involvement in disease.

https://www.pbimmunomics.com
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PDC*line Pharma

PDC*line Pharma is a French-Belgium clinical-stage biotech company that develops a new class of active immunotherapies for cancer based on an allogeneic cell line of Plasmacytoid Dendritic cells (PDC*line) loaded with cancer antigens. PDC*mel, our first drug candidate is currently in phase 1 clinical trials for melanoma. PDC*lung is in preclinical development for lung cancer.
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Our approach can be applied to virtually any type of cancer and any patient population, and combined with differents cancer treatments.


http://pdc-line-pharma.com/
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Pharmaleads SA

Pharmaleads aims to provide patients suffering from severe chronic and acute pain with improved pain relief without the side effects associated with other classes of analgesics.

​Based on years of experience in the design of highly potent and specific inhibitors of enkephalinases, Pharmaleads has developed a new class of analgesics called DENKIs (Dual Enkephalinases inhibitors). These small molecules are able to provide patients with local and sustainable pain relief.


Pharmaleads’ DENKIs are first-in-class drugs with a novel mechanism of action tackling pain by using endogenous enkephalins, natural peptides that specifically bind to pain-related opioid receptors to naturally modulate pain without the side effects observed with exogenous opioid drugs that also bind to other opioids receptors, not involved in pain control, triggering multiple side effects. Pharmaleads believes its products can change the lives of the many patients who are in need of improved treatment options for their chronic and/or acute pain, and could offer healthcare providers with an improved pain management option that helps address the opioid epidemic.

http://www.pharmaleads.com/
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​Polyneuron Pharmaceuticals AG

Polyneuron is a pharmaceutical spin-off of the University of Basel founded in late 2014, building on excellent expertise in carbohydrate-based drug discovery and clinical neurology. The company’s Antibody-Catch™ technology platform enables the chemical design of injectable glycopolymers. These glycopolymers are designed to selectively eliminate autoantibodies in autoimmune disease patients, while leaving the immune system intact.

This pioneering therapeutic approach holds great potential for effective and safe treatments for antibody-mediated autoimmune diseases. Polyneuron’s platform focus in on rare but devastating autoimmune diseases of the nervous system with an unmet medical need and where the pathological role of anti-carbohydrate autoantibodies is well established.

With funding of about CHF 5 million to date, Polyneuron delivered a preclinical proof of principle with its main asset PN-1007 for the treatment of anti-MAG neuropathy and obtained the orphan drug designation from the European Medicines Agency. In addition, the basis could be laid for a promising pipeline – the Antibody-Catch™ technology platform has a broad applicability scope and can be used to target carbohydrate-binding proteins in the broadest sense. Polyneuron strives to make Antibody-Catch™ a clinical reality and hopes to make a difference in the lives of people suffering from devastating diseases.

​https://polyneuron.com/
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​Rejuvenate Biomed NV

Rejuvenate Biomed, an independent Belgium based R&D company and spin-out from Janssen Pharmaceutical companies of Johnson and Johnson, was established in October 2017. The Company aims to increase the healthy years of life, also referred to as health span, by repositioning prescription drugs to the field of healthy aging. Rejuvenate Biomed focuses on the intersection between fundamental aging mechanisms & processes at cellular and molecular level that lead to chronic age-related diseases, investigating ways to delay or prevent the onset of age-related diseases. 

Quote: “We are living longer than ever before in the history of humankind. Our life expectancy has doubled, compared to  just a century ago - an incredible achievement of science and medicine. However, around the age of 65, age-related diseases start to impact our lives. Imagine that there is a way to stay healthy while aging, providing you with several decades to do the things you enjoy, to contribute to the wealth of society, to give back the acquired knowledge and to enjoy life with the ones you love. This dream seems to become reality since the process of aging can be influenced by drugs, and it is our goal to identify and develop these drugs for use in humans.”

Rejuvenate Biomed secured its seed investment in November 2017, supporting the validation of the pharmacology platform and preparation for the clinical activities. Recently,  Rejuvenate Biomed got awarded with a 0,5 M€ non-dilutive grant from VLAIO. Currently, they are in the process of raising series A funding.

​https://www.rejuvenatebiomed.com/en
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Selvita S.A. - [​WSE: SLV]

Selvita  is  one  of  the  largest  drug  discovery  companies  in  Europe  engaged  in the  research  and  development  of  breakthrough  small  molecules  therapies  in oncology. The company also have integrated drug discovery services division. Selvita  is  headquartered  in  Krakow,  Poland,  with  a  second  research  site  in Poznan, Poland and foreign offices located in Greater Boston Area, San Francisco Bay Area and Cambridge, UK. Selvita employs over 470 people including 150 with PhD.

The most advanced Selvita’s program is SEL24, a dual PIM/FLT3 kinase inhibitor, which has entered the clinic in March 2017, and was subsequently licensed to Menarini Group.

The second most advanced program is SEL120, a first-in-class small molecule inhibitor of CDK8 with potential use in hematological malignancies, colorectal cancer and breast cancer is currently developed in partnership with The Leukemia and Lymphoma Society.

Selvita Early Discovery programs include: Immunooncology platform, Epigenetic platform, program targeting metabolic abnormalities in cancer, as well as an early discovery stage programs in the area of protein kinases.

The company has alliances and partnerships with more than fifty large and medium-sized pharmaceutical  and  biotechnology  companies  from  USA  and  Europe, including R&D partnerships with Merck, H3 Biomedicine, Nodthera Therapeutics, as well as Menarini Group and The Leukemia and Lymphoma Society.

https://selvita.com/
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Sensorion SA - [​EPA: ALSEN]

Sensorion is a biopharmaceutical company, formed in 2009, focused as a “pure player” on developing therapies for debilitating inner ear disorders. With our primary strength in the inner ear and neurosciences, we combine world-class scientific excellence and top-tier execution capabilities to deliver first-in-class therapeutics. Sensorion was initially founded by French and European academics, and has now diversified its core competencies by recruiting a network of partners and key opinion leaders. Our leadership has exceptional, solid experience in research, marketing and finance.

http://www.sensorion-pharma.com/en/
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​Stalicla SA

STALICLA is an autism spectrum disorder (ASD) focused, data guided, drug development biotech company incorporated in May 2017. Through an innovative algorithm-based platform (DEPI) STALICLA has been able to identify non-behavioral subgroups of patients with idiopathic ASD and corresponding first-in class treatment candidates, thus pioneering personalized medicines for ASD.

http://stalicla.com/
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TapImmune Inc. - [NASDAQ:TPIV]

TapImmune  Inc.  is  a  leader  in  the  development  of  novel  immunotherapies  for cancer, with multiple Phase 2 and Phase 1b/2 clinical studies currently ongoing for the treatment of ovarian and breast cancer. The company’s peptide- or nucleic acid-based immunotherapeutic products comprise multiple naturally processed epitopes (NPEs) designed to comprehensively stimulate a patient’s killer T-cells and helper T-cells, and to restore or further augment antigen presentation  by  using proprietary nucleic  acid-based  expression  systems.  This  unique approach can produce off-the-shelf T-cell vaccine candidates that elicit a broad- based T-cell response and can be given without respect to HLA type. The company’s technologies may be used as stand-alone medications or in combination with other treatment modalities.

TapImmune is advancing two clinical stage T-cell vaccine candidates in multiple Phase II and Phase Ib/IIa clinical trials for treating ovarian and breast cancers, including programs in ovarian cancer that will benefit from FDA Fast Track and Orphan Disease Designation. The company is working in collaboration with industry and clinical leaders including Mayo Clinic, Memorial Sloan Kettering Cancer Center, and AstraZeneca.

https://tapimmune.com/
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​Themis Bioscience GmbH

Themis has developed a sophisticated vaccine platform and broad pipeline based on the advanced understanding of immune system mechanisms. Initially focused on preventing infectious diseases, the Company has demonstrated the potential of its versatile platform through the rapid progression into Phase 2 clinical development for a vaccine against Chikungunya, a debilitating disease with global outbreak potential. Funded to date by leading EU-based VCs, Themis has also gained prestigious non-dilutive funding for emerging infectious disease indications. The Company will apply its platform and manufacturing capabilities to diseases with high market potential both alone and for its partners.

https://themisbio.com/
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​Topas Therapeutics GmbH

Topas Therapeutics GmbH is a private Hamburg, Germany-based biotechnology company focused on developing products to address areas of major unmet need,  including  autoimmune  diseases,  allergies  and  anti-drug  antibodies.  The Company was spun out of Evotec in 2016.

Topas’ technology platform induces antigen-specific immune tolerance by harnessing the liver’s natural immunology capabilities. The Company has two programs preparing to enter the clinic in 2019 – one for an orphan disease and one for multiple sclerosis.

Topas also has a research and option agreement with Eli Lilly and Company fo- cused on immune tolerance and a co-development agreement with Evotec for a Type 1 diabetes program that is currently in pre-clinical testing.

Topas’  investors  include:  Epidarex  Capital,  Gimv,  EMBL  Ventures,  Evotec  and Boehringer Ingelheim Venture Fund.
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https://topas-therapeutics.com/
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Vaximm

VAXIMM is a privately held, clinical stage, Swiss/German biotech company developing oral T-cell immunotherapies for patients suffering from cancer.

VAXIMM’s technology is based on first-in-class oral T-cell activators using modified attenuated bacteria that can be readily adapted to target a wide range of cancer-related antigens.

The Company’s lead product candidate, oral VXM01, currently in clinical trials, activates killer T-cells targeting tumor vasculature and certain immune-suppressive cells and causes increased inflammation in solid tumors.

VAXIMM completed a Phase I/II trial of VXM01 in advanced pancreatic cancer. Clinical trials are completed or ongoing in metastatic colorectal cancer and in recurrent glioblastoma (brain cancer).


The Company has several additional product candidates at various stages of preclinical development. These candidates can be developed as stand-alone therapies or in combination with other immunotherapies, including VXM01.

Investors in our company include: BB Biotech Ventures, Merck Serono Ventures, Sunstone Capital and BioMed Partners.

​VAXIMM AG is headquartered in Basel, Switzerland with a wholly owned subsidiary, VAXIMM GmbH (Mannheim, Germany), from where the Company’s development activities are orchestrated, and a laboratory in Regensburg, Germany.


​http://www.vaximm.com/
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