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20-minute presenters

ARTCLINE GmbH

ARTCLINE is developing a novel cell-based extracorporeal immunotherapy (ARTICE®) that restores the immune function of sepsis patients and improves clinical outcomes. ARTICE® already fulfills all regulatory requirements in Germany and is set to be launched on the German market in the second half of 2026.
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Currently, ARTICE® is being validated in a randomized controlled, multicenter clinical trial (n=142 patients) at 20 intensive care units across Germany. Completion and read out of the trial is expected soon. More than 129 patients have already been enrolled. The last interim results are highly promising: there is a clear positive trend in survival and at fewer serious secondary infections – strong evidence of ARTICE®’s clinical potential. Please note that this trial is not a regulatory requirement but a marketing trial to confirm the safety and tolerability and clinical benefits of ARTICE® therapy.

ARTCLINE is well financed to complete the ongoing clinical trial.

Preparation for the commercial market launch in Germany have started and will accelerate following the read out of the clinical trial.

Given the enormous medical need and the strong clinical and regulatory progress, ARTCLINE offers an excellent opportunity for forward-looking investors to participate in the next stages of value creation related to market entry.

Key benefits at a glance:
• New therapeutic approach for the treatment of sepsis - immune cell-based extracorporeal procedure to strengthen the immune competence of patients with septic shock
• Interim clinical results show positive trends in survival and secondary infections
• Study completion imminent, read out in 2026
• Funding for the completion of the clinical trial is secured
• Preparation for go to market in Germany ongoing

The team would be happy to personally walk you through the upcoming roadmap at the DxPx.​

www.artcline.de

BioTalent

BioTalent | Talent Science™
Recruitment & Predictive Workforce Engineering for Biopharma

Workforce volatility is one of the most significant unmanaged risks in biopharma, quietly costing manufacturing sites £5–15M annually, while 89% of executives are unable to quantify its impact. The most expensive and volatile asset on the balance sheet, talent, often remains unmeasured and unmanaged with the same precision applied to equipment, supply chains, or intellectual property.

Critical shortages across automation, QA/QC, digital, AI and advanced manufacturing capabilities now affect approximately 70% of firms. Traditional HR metrics describe headcount, attrition, and hiring lag, yet they do not predict execution risk, measure workforce drag, or demonstrate return on investment.

Evidence consistently shows that workforce performance drives up to 23% of EBITDA variance in complex operations. Despite this, most leadership teams lack predictive visibility into where execution risk will emerge next.

Our Approach
BioTalent combines specialist recruitment expertise with Talent Science™, a quantitative workforce modelling platform designed specifically for biopharma.

Talent Science™ treats the workforce as a performance system. Using predictive analytics, complexity modelling, and risk quantification frameworks such as Talent Efficiency (TE), the Biopharma Talent Index (BTI), and Workforce Value-at-Risk (WVaR), we measure and optimise capability alignment, decision flow, succession depth, volatility exposure, and transformation readiness.

This enables leadership teams to:
Quantify workforce-driven execution risk
Prioritise high-impact hires rather than reactive hiring
Reduce dependency on critical individuals
Align digital and automation strategy with capability readiness
Engineer workforce stability as portfolio complexity increases
Recruitment is then deployed with precision
Measurable Outcomes
15–25% uplift in automation and digital transformation ROI
$5–15M annual risk reduction through volatility management
2–5% EBITDA improvement within 12–18 months

What Makes BioTalent Different
We combine sector-leading biopharma recruitment capability with predictive workforce engineering, linking talent decisions directly to operational throughput, risk reduction, and enterprise value. 

www.biotalent.com

eleva GmbH

Next-level medicine with ease – powered by moss.

Eleva is a clinical-stage biopharmaceutical company developing novel therapies and unlocking difficult-to-produce biologics based on a transformative manufacturing platform.

The company’s innovative drug development activities currently focus on complement disorders and enzyme replacement therapies, with wider potential across a range of disease areas.
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www.elevabiologics.com

Intelligencia AI

Intelligencia AI is a technology company that develops artificial intelligence (AI) and software solutions designed to de-risk and streamline the drug development process. Founded in 2017, the company uses machine learning and curated data to estimate the probability of success (PoS) for clinical trials, helping pharmaceutical and biotechnology companies make better decisions and reduce the high costs and long timelines associated with drug development.​

www.intelligencia.ai

IOmx Therapeutics AG

iOmx is a clinical-stage biotech company that harnesses deep tumor immunology insights to generate novel breakthrough I/O therapeutics for the most prevalent solid tumor indications. The company is translating unexplored immune evasion biology into a growing pipeline of multi-functional powerful biologics with single-agent activity that overcome resistance in major solid tumors. By applying its comprehensive drug discovery & development expertise, iOmx is committed to shaping the future of cancer therapy. 

iOmx is backed by international venture capital investors, such as ATHOS, Sofinnova Partners, Wellington Partners, MIG Capital, M Ventures as well as Arvantis. iOmx was founded in 2016 and is based in Munich. 
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www.iomx.com

Nimvec Therapeutics BV

Nimvec Therapeutics has developed a groundbreaking non-immunogenic repeated dose-enabling viral platform to deliver any transgene of choice into humans. It is advancing a pipeline of transformative, potentially curative gene therapies for a range of rare and prevalent diseases, including monogenetic indications, autoimmune diseases and chronic inflammation.

Nimvec™ AM510 is a tolerance inducing gene therapy for the treatment of Type 1 Diabetes. Diabetes is an autoimmune disease where self-reactive T lymphocytes selectively attack and destroy insulin-producing β cells lodged within the pancreas, leaving the patient unable to maintain glucose homeostasis. Proinsulin (PI) is considered to be the primary self-antigen involved in the autoimmune β cell destruction. To date, Type 1 Diabetes cannot be cured and the glucose homeostasis can be more or less maintained in patients by daily insulin injections. Although Diabetes is seen as a manageable disease nowadays, secondary complications of the current therapy are considerable and lead to significant morbidity and mortality. Using Nimvec™ AM510 we intend to restore the immune tolerance to proinsulin and potentially cure the patients.

www.nimvec.com

Optigo Biotherapeutics Inc.

Optigo Biotherapeutics is an innovative pre-clinical stage biotherapeutics company working to develop cutting-edge treatments to address vision loss from chronic ophthalmic diseases.

www.optigobio.com

Rejuvenate Biomed NV

Rejuvenate Biomed is a clinical-stage, AI-enabled biopharma company developing oral combination therapies for age-related diseases. Its lead asset, RJx-01, has shown strong safety and clinical efficacy in human sarcopenia studies with a disease-modifying mechanism of action. Phase 2b readouts are expected in 2026 and 2027. Powered by the proprietary CombinAge® (AI) and CelegAge® (in vitro) platforms, the company is building a broader aging pipeline. 

Rejuvenate Biomed is actively seeking strategic partnerships for RJx-01, as well as platform and pipeline collaboration. Further, Rejuvenate Biomed is raising a Series C to advance RJx-01, bring RJx-03 and RJx-07 into the clinic, and scale its discovery platforms.

www.rejuvenatebiomed.com

Ryvu Therapeutics S.A.
[WSE: RVU]

Ryvu Therapeutics is a clinical-stage drug discovery and development company focused on novel oncology therapies that address emerging targets in oncology. Ryvu’s pipeline includes a first-in-class CDK8/19 inhibitor romaciclib (RVU120, SEL120) , with encouraging signs of efficacy in Phase II across heme malignancies, and a broad pipeline of novel precision medicine, synthetic lethality and ADC payload assets.

Ryvu’s most advanced program is romaciclib (RVU120, SEL120) , a selective CDK8/CDK19 kinase inhibitor with broad potential in hematological malignancies. RVU120 is currently in Phase II development (i) in combination with venetoclax for the treatment of patients with r/r AML – the RIVER-81 study, (ii) as a monotherapy for the treatment of patients with lower-risk myelodysplastic syndromes (LR-MDS) – the REMARK study, (iii) as a monotherapy and in combination with ruxolitinib for the treatment of patients with myelofibrosis (MF) – the POTAMI-61 study.  

RVU305, a potentially best-in-class, brain-permeable PRMT5 inhibitor to treat multiple solid tumors, is currently in IND/CTA-enabling studies.   

Ryvu is also pursuing novel precision oncology and synthetic lethality targets through its ONCO Prime platform, which uses patient-derived cells to discover innovative targets across a variety of tumor types.  

In addition, Ryvu is developing several novel ADC payloads, building on its experience with STING-based ADCs that are being developed in collaboration with Exelixis. 

Ryvu also has key collaborations with Menarini and BioNTech. Dapolsertib (MEN1703, SEL24) is a dual PIM/FLT3 kinase inhibitor licensed to the Menarini Group that is currently being investigated in a Phase II study in diffuse large B-cell lymphoma (DLBCL) – the JASPIS-01 study. With BioNTech, Ryvu has a target-based drug discovery collaboration in immuno-oncology. 

Ryvu was founded in 2007 and is headquartered in Kraków, Poland. It is listed on the Warsaw Stock Exchange and is a component of the sWIG80 index. 

www.ryvu.com

TAXIS Pharmaceuticals, Inc.

TAXIS is developing drugs to kill bacterial Superbugs - antimicrobial resistant pathogens that have become difficult if not impossible to treat.  We are breaking the mold of traditional antibiotic drug development that for decades has yielded incremental innovations on old themes - generation X drugs that have pre-existing resistance.  TAXIS has discovered 3 entirely new classes of antimicrobials, each with its own unique mechanism of action - transformational innovation.

Our science, technologies and team have been validated by the World Health Organization, FDA and NIH, the latter of which granted TAXIS $5.6M to rapidly advance 2 of our novel drug candidates to the clinic.  Our third potentially breakthrough drug candidate, an oral anti-MRSA agent, completed Phase I (FIH) study successfully and will be entering Phase II in 2026.

www.taxispharma.com

Vidac Pharma Holding PLC
[​ETR: T9G]

Vidac Pharma is a clinical-stage biopharmaceutical company advancing first-in-class oncology and onco-dermatology therapies based on a novel approach to cancer metabolism.

The company’s research focuses on targeting abnormal metabolic processes that characterize cancer cells, with the objective of restoring normal cellular regulation and inhibiting tumor progression. Vidac’s scientific platform targets the Warburg effect and forms the foundation of its clinical development programs and pipeline.

Founded in 2012, Vidac Pharma is led by Prof. Max Herzberg and a multidisciplinary leadership team with extensive experience in drug development, life sciences, and corporate management. The company is supported by an international network of scientific and clinical advisors.

Vidac’s lead compound, VDA-1102, is in clinical development for actinic keratosis and cutaneous T-cell lymphoma (CTCL). A next-generation candidate, VDA-1275, is currently in preclinical development, with potential application across a range of solid tumors.

Vidac Pharma maintains a strong intellectual property portfolio and operates within a structured governance and quality framework appropriate for a publicly traded life sciences company.

Vidac Pharma Holding PLC (T9G) is publicly traded on Xetra (Frankfurt Stock Exchange) and the Tradegate Exchange (Germany).

www.vidacpharma.com

10-minute presenters

Abalos Therapeutics GmbH

Abalos is a clinical stage company developing a transformative approach to overcome cancer immunotherapy hurdles and break down solid tumors. 
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Abalos is preparing for the next financing round to expand clinical trials with our lead product ABX-001 and to broaden our product pipeline. Abalos offers a unique investment opportunity with multiple milestones in the next 12 months, including early clinical validation of our technology and expansion of our pipeline.

After a single i.v. administration, our products  induce exceptional levels of effector t-cells and actively guide these and other immune cells into the primary tumor and distant metastases. Furthermore, our technology creates an inflamed tumor environment, which results in further boosting  of anti-tumor activity.   We achieve this by leveraging and optimizing the well-described properties of arenaviruses as a platform for replicating  (non-oncolytic) viro-therapeutics for systemic use.
Our lead product  ABX-001 is in clinical testing. It has shown strong  efficacy in pre-clinical studies against a broad range of tumors and has a very clean pre-clinical safety profile, including excellent safety at high doses in non-human primate studies. A robust and scalable cGMP manufacturing process has been established. 

Clinical trials with ABX-001 started in Q4 2025, with interim results expected in Q2 of this year. Based on its unique mechanism of action, ABX-011 has potential benefit  in a broad range of cancers, including tumors that are not responsive to immuno-therapy or that have developed resistance to checkpoint inhibitors. ABX-001 is well suited for monotherapy, but is also well positioned to be combined with other modalities such as chemotherapy, CPIs, T-cell engangers, ADCs and cell therapy.

Beyond ABX-001, Abalos is developing the next clinical candidate, that adds specific activity to the benefits offered already by ABX-001. Pre-clinical PoC for the next compound is expected in the coming 12 months.
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www.abalos-tx.com

AM-Pharma B.V.

AM-Pharma, a private biotech company based in Utrecht, the Netherlands, is developing its proprietary recombinant human alkaline phosphatase therapeutic, ilofotase alfa as two distinct products: 1) for prevention and treatment of acute kidney injury, ph2 read out around end 2025 and 2) as an enzyme replacement therapy administered sc for the rare disease hypophosphatasia, clinical PoC achieved.

www.am-pharma.com

Ervimmune

ErVimmune is a French preclinical biotechnology company founded in October 2019 by Prof. Stéphane Depil, an onco-hematologist and researcher at the Centre Léon Bérard and Cancer Research Center of Lyon. A spin-off from the Centre Léon Bérard, ErVimmune specializes in developing next-generation cancer vaccines and cell therapies that target ‘cold tumors’ - cancers that do not respond to current immunotherapies.

The company’s innovative approach is based on identifying and selecting new sources of unconventional tumor epitopes derived from human endogenous retroviruses (HERVs). Because of their similarity to viral protein fragments recognized as foreign by the immune system, HERV-derived antigens are prime targets, shared by different tumors, for the development of cancer vaccines and T-cell based immunotherapies, especially in tumors that respond poorly to current treatments. The first indications represent two major unmet medical needs: triple-negative breast cancer (TNBC), accounting for approximately 15% of breast cancer cases worldwide and known for its aggressivity, and ovarian cancer, the deadliest cancer among women globally.

www.ervimmune.com

ExpreS2ion Biotech Holding AB
[Nasdaq FN: EXPRS2]

ExpreS2ion is a clinical-stage biotechnology company developing next-generation immunotherapies and vaccines based on its proprietary ExpreS2 protein expression platform, in combination with Virus-Like Particle (VLP) technology used across several pipeline assets. The company’s capabilities enable efficient production of complex antigens and their presentation in highly immunogenic formats, supporting applications across oncology and infectious diseases.

ExpreS2ion’s lead clinical asset, ES2B-C001 (HER2-VLP), is a first-in-class therapeutic cancer vaccine currently in Phase I clinical development for advanced HER2-positive and HER2-low breast cancer, with dose escalation ongoing. Early clinical data indicate a favorable safety profile and induction of HER2-specific immune responses. Topline Phase Ia data are expected in the second half of 2026, with Phase Ib data anticipated by the end of 2026.

Beyond its lead program, ExpreS2ion maintains a diversified pipeline and a strong track record of partnerships, having produced hundreds of recombinant proteins and VLP-based constructs for academic and industry collaborators. This platform-driven approach provides multiple opportunities for value creation through internal development, strategic collaborations, and partnering.

www.expres2ionbio.com

Fapon Biopharma

Fapon Biopharma develops biologics targeting cancers, autoimmune disorders, CNS diseases, and other unmet medical needs. Our platforms include FILTEN (IL-10M Fusion Protein), Bi/Tri-TCE (VHH-based), targeted LNP delivery with bi-specific antibody ligands, PROTiNb, and more. With a differentiated pipeline and end-to-end capabilities from discovery to early clinical development, we are dedicated to delivering innovative medicines that improve patient outcomes worldwide.

www.faponbiopharma.com

HEPHAISTOS-Pharma

At Hephaistos, we are developing 3rd generation innate immune boosters with improved safety profile for intravenous use. They are designed to restore effective anti-tumor immunity in patients who don’t respond to current immunotherapies.

Our novel immunotherapy strategy enables controlled activation of innate immune cells. We turn tumor-supporting macrophages in the tumor-microenvironment into cancer killers and boost dendritic cells functions, the master regulator of immunity. This subsequently activates memory tumor killing lymphocytes, driving a precise, broad, and durable immune response to overcome immune resistance, prevent relapse and even tackle metastases.

Our lead drug candidate is a systemically active high-therapeutic-index TLR4 activator generated from our first-in-class proprietary engineering platform with strong patent protection. In parallel, Hephaistos is developing next-generation adjuvants that maximize long term protection of vaccines.

Our differentiation lies in our ability to:
• Drive precise, controlled activation of innate immunity 
• Reshape the tumor microenvironment to boost local anti-cancer immunity
• Strengthening long-lasting T-cells response 
• Avoid the systemic toxicity historically associated with broad immune stimulators
• Enable intravenous injection which opens the way to treating hard to access tumors and metastatic patient which all together represents 80% of the patients. 

This approach should be a game changer for immunotherapy and intravenous administration is the holy grail for innate immune boosters. EIKON, a US competitor, just raised 351M$ last year with an intravenous TLR7 innate immune booster. We want to be in the clinic as the third-generation TLR agonis wave accelerates and enters a new deal cycle - like ADCs did five years ago!

I would also emphasize that this is a French and European breakthrough, and obviously that industrial and medical sovereignty are more important than ever.

www.hephaistos-pharma.fr

Intragel Therapeutics Ltd.

Intragel Therapeutics has introduced a novel long-acting injectable (LAI) platform, SRGel, that allow single and safe application of drugs replacing multiple dosing for patients and reducing side effects with prolonged exposure of days to months of small molecules, peptide and biologics. SRGel is already clinically validated through phase 1 study in oncology space for patients that are unfit for systemic therapy and surgery.

www.intra-gel.com

invIOs GmbH

In a nutshell, invIOs is a privately held biotech company focused on discovering and developing innovative cancer immunotherapies. In the field of glioblastoma, we have an ongoing collaboration with the Dana-Farber Cancer Institute, Boston, Mass. (Harvard Medical School). invIOs was founded in 2022 from a spin-off of early-stage projects from APEIRON Biologics AG, which was sold to a US pharmaceutical company in 2024. invIOs is based in Vienna, Austria.

www.invios.com

Khondrion BV

Khondrion is a European phase-3 biopharmaceutical company developing a first-in-class, disease-modifying therapy for primary mitochondrial disease, initially targeting patients carrying the m.3243A>G mutation. This genetically defined population suffers from a chronic, progressive, multi-system disorder characterized by severe fatigue, muscle weakness, cognitive impairment, and reduced quality of life. There are currently no approved disease-modifying treatments addressing the underlying disease biology.

Khondrion’s lead compound is an orally available small molecule designed to modulate pathological redox signaling and restore mitochondrial function. The program is supported by a substantial body of clinical data, including randomized controlled studies and long-term follow-up, demonstrating clinically meaningful and durable improvements across patient-relevant domains, including fatigue, physical functioning, and cognition. These domains were selected based on patient input and align with regulatory expectations in rare metabolic and neurological diseases.

Following regulatory interactions in both Europe and the United States, Khondrion has initiated its pivotal Phase 3 program, with first patient in achieved and the initial wave of patients fully funded. The Phase 3 design builds on prior clinical experience and aims to support registration while preserving flexibility for geographic expansion and future lifecycle development.

Khondrion is backed by a stable syndicate of family offices and patient representatives with a long-term investment horizon. The company operates with a disciplined capital allocation strategy focused on late-stage execution, regulatory readiness, and value creation toward NDA submission.

www.khondrion.com

Laverock Therapeutics Ltd.

Laverock Therapeutics is powering the development of disease-responsive advanced therapies through our unique, programmable gene control technology. Our innovative platform harnesses the cell’s natural regulatory mechanisms to deliver programmable and tunable gene control through recoded miRNAs. This enables the development of highly effective medicines with enhanced precision and improved safety profiles.  

Utilising our platform technologies, we are working to develop the next-generation of advanced therapies, both through our own pipeline – targeting oncology and genetic medicine – and through partnerships. 

Laverock has a highly experienced leadership team with proven track records in biotechnology, pharma and academia and an exceptionally strong Board. Laverock has raised more than £20m seed funding to date from high-calibre investors including Calculus Capital, Eli Lilly and Company, Mercia Ventures, Maven Capital Partners, Eos Advisory, UK Innovation & Science Seed Fund, Tekfen Ventures and Norcliffe Capital.

www.laverocktx.com

LiveKidney.Bio Ltd.

LiveKidney is a clinical stage biotech company advancing a proprietary, off the shelf MSCs based therapy for kidney related non-communicable comorbidities, aiming to improve the health span and lifespan for kidney patients, derived from autoimmune diseases and metabolic disorders. 

The company’s products are based on proprietary, cell-shielding formulations of mesenchymal stromal cells (MSCs) that promote the continuous release of therapeutic bioactive compounds, producing beneficial paracrine systemic and multiorgan effects using selected and unique routes of administration. The company’s products address major hallmarks of aging, modulating the immune system, reducing inflammation and fibrosis and improving mitochondrial activity, thereby improving kidney function.
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www.livekidney.bio

Metys Pharmaceuticals AG

Metys Pharmaceuticals AG is pioneering next-generation treatments for neuropathic pain and cognitive impairment with our patented non-racemic dimiracetam, MP-101 — a 3:1 R-to-S enantiomer mixture that's significantly more potent than its racemic predecessor.

Building on a successful Phase 2 trial in 117 patients showing safety and promising efficacy against HIV-associated pain, we've secured worldwide patents and FDA confirmation to leverage existing data for accelerated development.

We're now advancing MP-101 into a Phase 2 trial to prevent oxaliplatin-induced cold sensitivity in colorectal cancer patients, with proven preclinical results across broader neuropathic and cognitive models.

We seek CHF 20 million in two tranches: 1.5 million for initial cGMP production and regulatory submissions, followed by 18.5 million post-approval for the trial. This positions us for rapid value creation in a multi-billion-dollar market.

Let's partner to bring this breakthrough to patients—I'm Mike Scherz, founder and CEO.

www.metys-pharma.ch

O11 Biomedical GmbH

O11 Biomedical is a pharmaceutical startup from RWTH Aachen University developing a breakthrough oral therapy for hypercapnia in severe COPD. Its patented CO₂-absorbing microparticles enable effective CO₂ removal via the gut, offering  a patient-friendly alternative to non-invasive ventilation with superb effectivity.​

www.o11-biomedical.com

Phoremost Ltd.

PhoreMost is a Cambridge UK-based biotechnology company dedicated to turning scientific breakthroughs into life-changing cancer therapies. The company has a number of disclosed alliances with partners, including Roche and Boehringer Ingelheim.
 
PMC-001 | Phase-1 ready asset positioned for solid tumours including brain metastasis.

PMC-002 | Novel synthetic lethal target for treatment of HPV+ cancers
 
PMC-003 | Degrader driven by novel ligase to overcome limitations of pan-BRD4i
 
TPD Platform | ‘Beyond Cereblon’ chemical ligase platform(s) for protein-of-interest degradation and pipeline expansion.

www.phoremost.com

StemSight Oy

StemSight is a pre-clinical stage biopharma company developing proprietary hypoimmune, allogeneic cell-based therapies derived from human induced pluripotent stem cells (iPSCs) to treat blindness. Our technology platform using proprietary differentiation methods and biomaterial carriers have spun out two different products. We showcase our technology in the rare disease limbal stem cell deficiency, a high-reimbursement-potential unmet need, while looking to expand the platform to more major indications.​

www.stemsight.fi

Superbranche 

SUPERBRANCHE is a nanomedicine company specializing in imaging, therapy monitoring and theranostics. It has a technological platform for the development of new generation nanomaterials.

www.superbranche.com

Rising Stars Session

elaris flexco

ELARIS is a biotechnology company developing next-generation bacterial vaccines that preserve health and quality of life, particularly in aging populations. The company’s lead program is a highly differentiated vaccine against Clostridioides difficile (C. difficile), a severe hospital-acquired diarrheal infection that disproportionately affects elderly and vulnerable patients. By shifting the focus from treatment to prevention, ELARIS aims to reduce hospitalizations, antibiotic use, and the growing burden of antimicrobial resistance.​

www.elaris.com

Epitome Therapeutics FlexCo

Epitome Therapeutics is developing a new therapeutic modality for precise and durable activation of endogenous genes through epigenetic programming. The company focuses on genetic and metabolic diseases, with initial programs in liver-directed indications. Epitome is led by an experienced management team with a strong track record in building and advancing innovative biotechnology companies.​

www.epitome-tx.com

​Hemastatx GmbH

Profile coming soon...

kez.biosolutions GmbH

kezbio is developing a drug discovery platform for unstructured and intrinsically disordered proteins (undruggables). 

We integrate fragment-based approaches with activity-based-probes and fast chemoenzymatic biocatalysis for fast and lean discovery.

www.kez.bio

Meddenovo Drug Design SAS

Meddenovo Drug Design is a Lyon-based drug design company developing cyclic peptide therapeutics for oncology and radiopharmaceuticals. The company was founded to address a fundamental bottleneck in early drug discovery: the difficulty of generating viable lead candidates for complex and hard-to-drug targets when no starting molecule exists.

Meddenovo is incubated at Bayer Life Hub, benefiting from a strong innovation ecosystem and close interaction with industry expertise. The company has raised €1.7M in total funding, combining equity and non-dilutive support. Meddenovo is also an i-Lab laureate, a highly selective French government deep-tech program that recognizes startups with high innovation potential, and significant growth prospects. Through this program, Meddenovo receives direct public funding and benefits from long-term institutional trust, reflecting national-level confidence in its technology and team.

After finalizing its pre-seed round in 2025, Meddenovo successfully achieved its planned development and business milestones. In less than two years, the company advanced its technology into a robust, ready-to-use AI platform dedicated to cyclic peptide drug design, which is now actively applied in drug discovery projects.

Meddenovo’s proprietary AI/ML-powered platform enables the de novo design and optimization of cyclic peptide drug candidates. Unlike traditional approaches that depend on prior experimental data or limited libraries, the platform allows rational exploration of a large and biologically relevant chemical space while prioritizing drug-like properties, target engagement, and functionalization potential. This makes the technology particularly well suited for oncology applications, including targeted radiopharmaceuticals.

Meddenovo advances its own internal pipeline while forming strategic partnerships with pharmaceutical companies. The company has already entered into a partnership agreement with a large pharmaceutical group, providing early industrial validation of its scientific approach and technology.

Meddenovo is currently preparing its seed financing round, planned to be finalized in 2026, to further advance its cyclic peptide pipeline and expand strategic partnerships in oncology.

​www.meddenovo.com​

Nerai Bioscience

Nerai engineers highly specific, clinically minded CRISPR editors using AI and high-throughput evolution. Designed for reusability, our editors can power multiple indications by changing only the guide RNA. With lead program validated in vivo (rare metabolic disease), we're now raising a Seed to broaden the pipeline into the ocular field.​

www.nerai.bio

QureTech Oncology

Newly formed company developing a new and potentially transformative treatment approach to colorectal cancer by targeting a bacterial protein used by the tumor to evade immune attack and immunotherapy. In vivo proof-of-concept study in syngeneic mice CRC model demonstrate how inhibition of the virulence factor can turn previously immunologically cold and resistant tumors responsive to anti-PD-1 immunotherapy.
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www.quretech.com

RIANA Therapeutics GmbH

First-in-Class STAT5 Oligomerization Inhibitors - Overcoming Drug Resistance in FLT3+ Acute Myeloid Leukemia.
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www.rianatx.com

Tandem Therapeutics AG

Tandem Therapeutics is a mechanomedicine company pioneering a new class of disease-modifying antifibrotics through mechano-targeted Peptide-Drug Conjugates (PDCs).  

Our proprietary peptides turn the fibrotic microenvironment, long considered a barrier to therapy and a key disease driver, into a selective delivery system, enabling potent and safe treatments for progressive fibrosis. The company’s lead program targets progressive pulmonary fibrosis, with a modular platform expandable across fibrotic organs.

www.tandem-tx.com

TheraPPI Bioscience SA

Moving beyond approved Ras-MAPK pathway inhibition, TheraPPI targets pathway dysregulation through a founder-identified PPI drug target. Robust preclinical data support the potential for superior and more durable therapeutic efficacy against cancer.
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​www.tppibio.com

Tuari Therapeutics GmbH

Profile to be added...

Ultimate Medicine AG

Ultimate Medicine (UM) is a Swiss preclinical biotech focused on maximizing the healthspan of patients with Alzheimer's disease and other dementias. The company is pioneering a class of small molecules targeting elevated levels of a novel toxic metabolite that disrupts critical neuronal functions and accelerates disease progression. The company’s lead program is an oral small-molecule inhibitor designed to block metabolite synthesis, thereby reducing systemic and brain exposure through natural clearance mechanisms.
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www.ultimatemedicine.com

Vectiopep

Vectiopep: Unlocking T-Cell Potency via Precision mRNA Delivery

Vectiopep is a preclinical-stage biotech pioneering a next-generation mRNA delivery platform designed to overcome the "liver-sink" limitations of current technologies. Our mission is to transform the treatment landscape for cold tumors, specifically Micro-satellite Stable Colorectal Cancer (MSS CRC), where standard immunotherapies often fail.

The Technology:
- Leveraging our proprietary, patented peptide-based mRNA vector, Vectiopep enables a fundamental shift in biodistribution. We achieve >99% selective delivery to the lymphoid organs, with negligible off-target liver accumulation.
- This precision triggers an unprecedented immune response, driving 10x stronger antigen-specific T-cell activation than industry-standard lipid nanoparticle (LNP) benchmarks, significantly widening the therapeutic window. ​

Pipeline & Status:
While our lead program focuses on MSS CRC, our platform’s superior biodistribution has broad-spectrum applicability, including in vivo CAR-T and high-potency preventive vaccination for complex pathogens. With our core patent granted and €1.2M in recent funding, we have finalized Lead Candidate selection and are now advancing toward Lead Compound selection in H2 2026.

​www.vectiopep.ee

virtual showcase

Duo Oncology

Duo Oncology is an oncology company reimagining chemotherapy, a foundational treatment for metastatic cancer. Its lead program, DUO-207, consolidates multi-drug chemotherapy regimens into a single, potent prodrug for pancreatic, lung, breast, and other inoperable cancers. DUO-207 is trial-ready, supported by completed IND-enabling studies, orphan designations, and strong preclinical benchmarks versus standard of care.

www.duooncology.com