Founded in 2010, Abionic developed its nanotechnology within the Swiss Federal Institute of Technology in Lausanne (EPFL). Already in 2012, Abionic obtained the ISO 13485 quality certification for research and development, production and marketing of products for the in-vitro diagnostics market and has successfully maintained its system since then. The company is benchmark in winning prices, 4 times best med-tech startup and many others. Abionic is now a scale up that has proven the functionality and value of its technology in the market and will grow not only its production capacities and test portfolio but also its international footprint.
Acesion Pharma ApS is a Danish biotech company founded in 2011 and based in Copenhagen. Acesion Pharma develops more efficacious and safe drugs for the treatment of atrial fibrillation (AF), the most common type of cardiac arrhythmia.
Existing drug therapies generally have a limited effect or are associated with risk of serious adverse events, and there is therefore a considerable patient need for developing better and safer drugs. Inhibition of SK channels, an ion channel with relevance for regulating the heart rhythm, constitute a new and promising principle for the treatment of AF.
Acesion Pharma aims to develop first-in-class SK channel inhibitors as a more efficacious and safe treatment of AF. Equity investors in Acesion Pharma are Novo A/S, Broadview Ventures, SEED Capital and Wellcome Trust. In 2013 Acesion Pharma received 27.9 million DKK (3.7 million EUR) as a Seeding Drug Discovery Award from the Wellcome Trust to fund the development of a novel drug for the acute treatment of AF.
Adocia is a clinical-stage biotechnology company that specializes in the development of innovative formulations of already-approved therapeutic proteins. Adocia’s portfolio of injectable treatments for diabetes, featuring five clinical-stage products and five preclinical products, is among the largest and most differentiated of the industry. The proprietary BioChaperone® technological platform is designed to enhance the effectiveness and/or safety of therapeutic proteins while making them easier for patients to use. Adocia customizes BioChaperone to each protein for a given application in order to address specific patient needs.
CHEMOTHERAPEUTIC Adocia’s clinical pipeline includes four novel insulin formulations for the treatment of diabetes: two ultra-rapid formulations of insulin analogs (BioChaperone Lispro U100 and U200), a rapid-acting formulation of human insulin (HinsBet U100) and a combination of basal insulin glargine and rapid-acting insulin lispro (BioChaperone Combo). Additionally, an aqueous formulation of human glucagon (BioChaperone Human Glucagon) has recently entered clinical testing. Adocia is also developing two combinations of insulin glargine with GLP-1s, (BioChaperone Glargine Dulaglutide and BioChaperone Glargine Liraglutide), two combinations of insulin lispro with synergistic prandial hormones (BioChaperone Lispro Pramlintide and BioChaperone Lispro Exenatide), and a concentrated, rapid-acting formulation of human insulin (HinsBet U500), all of which are in preclinical development.
Adocia aims to deliver “Innovative medicine for everyone, everywhere.”
Affimed is a clinical-stage biopharmaceutical company focused on discovering and developing highly targeted cancer immunotherapies. Its product candidates are being developed in the field of immuno-oncology, which represents an innovative approach to cancer treatment that seeks to harness the body’s own immune defenses to fight tumor cells. The most potent cells of the human defense arsenal are types of white blood cells called Natural Killer cells, or NK-cells, and T-cells. Affimed’s proprietary, next-generation bispecific antibodies, termed TandAbs® because of their tandem antibody structure, are designed to direct and establish a bridge between either NK-cells or T-cells and cancer cells. Affimed’s TandAbs have the ability to bring NK-cells or T-cells into proximity and trigger a signal cascade that leads to the destruction of cancer cells. Due to their novel tetravalent architecture (which provides for four binding domains), the TandAbs bind to their targets with high affinity and have half-lives that allow intravenous administration. Affimed believes, based on the TandAbs mechanism of action and the preclinical and clinical data it has generated to date, that its product candidates may ultimately improve response rates, clinical outcomes and survival in cancer patients and could eventually become a cornerstone of modern targeted oncology care.
Affimed has focused its research and development efforts on three proprietary programs for which it retains global commercial rights. Because TandAbs bind with receptors that are known to be present on a number of types of cancer cells, each of Affimed’s TandAb product candidates could be developed for the treatment of several different cancers. Affimed intends to initially develop its two clinical stage product candidates in orphan or high-medical need indications, including development as a salvage therapy for patients who have relapsed after, or are refractory to, that is who do not respond to treatment with, standard therapies.
Allena Pharmaceuticals is dedicated to developing and commercializing first-in-class, oral enzyme therapeutics to treat patients with rare and severe metabolic disorders that affect the kidney. The company is focused on metabolic disorders that result in excess accumulation of certain metabolites, such as oxalate and urate, that can cause kidney stones, damage the kidney, and potentially lead to chronic kidney disease, or CKD, and end-stage renal disease. Allena’s proprietary technological approach enables the design, formulation and delivery of non-absorbed and stable enzymes orally and in sufficient doses for activity in the GI tract. This approach utilizes the GI tract to degrade metabolites, such as oxalate and urate, reducing plasma and urine levels, and in turn, reducing their disease burden on the kidney over time. ALLN-177, Allena’s lead product candidate, is a first-in-class, oral enzyme therapeutic in late-stage clinical development for the treatment of hyperoxaluria, a metabolic disorder characterized by markedly elevated urinary oxalate levels due to either a genetic defect (primary) or from hyper-absorption of oxalate from the diet (secondary). Secondary hyperoxaluria can be due to an undefined cause (idiopathic) or as a result of underlying GI disorders (enteric). Kidney stones, often the first sign of hyperoxaluria, are painful and may require interventional procedures, for example. Severe hyperoxaluria in settings of enteric and primary hyperoxaluria may also damage the kidney and potentially lead to chronic kidney disease and end-stage renal disease. There are currently no approved therapies for the treatment of hyperoxaluria. Allena has conducted a robust clinical development program of ALLN-177, including three Phase 2 clinical trials, which demonstrated reductions of urinary oxalate excretion in patients with secondary hyperoxaluria, especially in patients with enteric hyperoxaluria. ALLN-177 has also been well tolerated in clinical trials to date. Based on these data, the high unmet medical need, and the enzyme’s specific mechanism of action, Allena’ lead program is focused on adult patients with enteric hyperoxaluria. The FDA also has granted separate orphan drug designations for ALLN-177 for the treatment of primary hyperoxaluria and for the treatment of pediatric hyperoxaluria. In addition, the European Commission has granted orphan designation for ALLN-177 for the treatment of primary hyperoxaluria. ALLN-346, Allena’s second product candidate, is being developed for patients with hyperuricemia and moderate to severe CKD. Hyperuricemia, or elevated levels of uric acid in the blood is commonly associated with gout as well as kidney stones and kidney disorders.
AMYRA is developing therapeutic product applications for the treatment of celiac disease and gluten sensitivity, which represent major public health issues. Both conditions are triggered by the ingestion of gluten, which is ubiquitously present in the Western diet and thus almost impossible to avoid.
Anagenesis is a preclinical‐stage stem cell-based company focused on developing novel treatments for genetic and age-related muscle degenerative diseases with unmet medical needs. A wide spectrum of diseases in which specific tissues are lost or damaged remain incurable. This reflects a lack of drugs to promote regeneration or of transplantable cells to replace those that are missing. One example of this urgent unmet need are the human conditions that lead to degeneration of skeletal muscle, ranging from muscular dystrophies and neuromuscular disease to muscle-wasting caused by disuse. However, to date, it has not been possible to generate muscle cells in sufficient quantity for high-throughput drug screening, or sufficient purity for cell-based therapy.
Patented new technologies licensed-in by Anagenesis have changed all this. Using stem cells as a renewable source, Anagenesis scientists first generated the natural embryonic precursors of skeletal muscle then devised protocols for turning the precursors into contractile muscle fibers in the culture dish. The resulting muscle cells are purer and more abundant than any before and successfully colonize damaged muscle when transplanted in vivo. Moreover, when stem cells from mice with muscle disorders are used, the resulting muscle fibers show characteristic disease-related defects in culture. The time is therefore ripe for drug screening to enhance muscle regeneration and/or correct disease phenotypes, and for a reasoned approach to therapeutic muscle reconstruction. Anagenesis has exclusive rights to two key patents from the French national biomedical research agency INSERM. Two main activities will generate revenues: a) Cell therapy for genetic muscle disorders b) Cell-based screening of small molecules
Anagenesis already secured its first private funding from the AFM (French muscular dystrophy association) to develop applications in the skeletal muscle therapeutic area.
Anergis SA is a Swiss-based biopharmaceutical company specializing in the discovery and development of novel allergy vaccines targeting the most frequent allergies. Allergies are the most prevalent and the fastest growing chronic conditions in the industrialized world with over 300 million people affected. While short-term symptomatic treatments of allergy need to be prescribed continuously, the only curative therapy of allergy, known as “desensitization” or “Specific Immunotherapy” (SIT), is a process of induction of tolerance to the allergen that today requires 3-5 years of treatment and poses the risk of serious side effects. Based on its proprietary Contiguous Overlapping Peptides (“COPs”) technology, which Anergis acquired from the University of Lausanne, Switzerland (UNIL), the Federal Institute of Technology (EPFL) and the Centre Hospitalier Universitaire Vaudois (CHUV), the company is developing innovative SIT products containing socalled COPs that reproduce the full amino acid sequence of the allergen in separate long peptidic molecules.
Anima Biotech is pioneering Translation Control Therapeutics, a new class of drugs that control protein translation. Our novel drug discovery platform enables a new therapeutic strategy to approach hard or undruggable protein targets where existing methods have failed for decades.
Our platform is enabled by a breakthrough, patented technology. Anima's Protein Synthesis Monitoring (PSM) technology enables for the first time the visualization and monitoring of protein synthesis by ribosomes in living cells in real time. We use this information in specialized high content screening methods to discover molecules that regulate protein translation, correcting problems in over-expression or under-expression of target proteins. The platform is the result of over a decade of development in collaboration with a broad network of 17 leading academia and research institutions that have validated and expanded the scope and reach of our technology. Anima's drug discovery pipeline is currently focused on four outstanding therapeutic areas where the underlying cause of the disease is closely linked to protein translation: Fibrosis (Collagen type I translation inhibitors), RSV (inhibiting the production of viral proteins by host cell ribosomes), Oncology (C-Myc translation inhibitors) and Huntington’s Disease (controlling the production of toxic proteins).
Protein translation is a major biological process and the ability to control it opens a new therapeutic strategy for many additional diseases. We seek to maximize the therapeutic potential of our platform by partnering with pharma companies in their drug discovery programs.
APEIRON Biologics AG, based in Vienna, Austria, is a clinical stage biotech company developing innovative products in cancer immunotherapy. The company was founded by Professor Josef Penninger and became operational in 2006. Apeiron currently employs about 45 people and is led by a management team with strong background in the biotech industry and drug development, especially in immuno-oncology.
Apeiron’s impressive track record in R&D of innovative projects has been validated by several license deals with Pharmaceutical companies (GSK for APN01, Sanofi for APN411, EUSA Pharma for APN311) and importantly by the marketing authorization in the EU for APN311 in May 2017 (dinutuximab beta; Qarziba®). APN311 is a monoclonal antibody for immunotherapy of pediatric neuroblastoma, a rare and severe childhood cancer.
Aptose Biosciences is a science-driven biotechnology company advancing first-in-class agents to treat life-threatening cancers, such as acute myeloid leukemia (AML), high-risk myelodysplastic syndromes (MDS) and other hematologic malignancies. Based on insights into the genetic and epigenetic profiles of certain cancers and patient populations, Aptose is building a pipeline of novel oncology therapies directed at dysregulated processes and signaling pathways. Aptose is developing targeted medicines for precision treatment of these diseases, based on a patient’s specific gene expression signature. In the treatment of cancer, this strategy is intended to optimize efficacy and quality of life by minimizing the cytotoxic side effects associated with conventional therapies.
AYOXXA Biosystems GmbH is a venture-backed life science tools company driving advances that empower translational proteomics, setting sights on better diagnostics and therapeutics. Presently entering the commercial phase of growth, our company is an international and multidisciplinary team of scientists, technicians, engineers and business professionals working relentlessly to realize our vision of enabling success in translational proteomics. Together, we have transformed an innovative technology exclusively licensed from the National University of Singapore in 2010, into a mature, groundbreaking protein analysis platform. Designed to deliver high-quality data on multiple proteins in the same small-volume sample, LUNARIS™ enables fully scalable quantitative validation of disease-relevantbiomarkers: from lab to clinic – from model to man – from data to insight.
We are an advanced clinical-stage drug development company creating the next generation of therapeutics to treat Alzheimer’s disease and other neuroinflammatory and neurodegenerative conditions. Our ongoing, Phase III Cognite Trial with ALZT-OP1, a combination therapy utilizing two small molecule drugs previously approved by the United States Food and Drug Administration. The company already has intellectual property protection (IP) protection for the platform use and actively pursuing IP protection on AD use, repurposing, dosing, combination and delivery of our novel treatment. Our in vitro, in vivo (in the APP/PS1 mouse model), and two Phase I clinical study results in normal and AD subjects support the potential efficacy of our combination therapy to combat the complex neurinflammation and neurodegeneration process associated with Alzheimer’s disease. Our research shows that this therapy has the potential to halt Alzheimer’s disease early in its development. The ongoing Phase III clinical trial of ALZT-OP1 the Cognite Trial in patients with symptoms of early Alzheimer’s disease is being conducted under a Special Protocol Assessment agreement with the FDA. Our goal is to complete this trial and be in a position to submit a New Drug Application by 2020.
BioElectron is a platform biotechnology company, with expertise in the electron transfer (redox) chemical reactions that underpin oxidative stress and inflammation in all biological systems. We are using this expertise in redox biochemistry to develop first-in-class therapeutics for unmet medical needs. Our therapeutic candidates target a select set of enzymes, called oxidoreductases, with known biological significance.
Our initial clinical focus is on developing treatments for inherited mitochondrial diseases primarily affecting children, where there are unambiguous genetic alterations in key oxidoreductase systems. Mitochondrial diseases share a common feature: defects in DNA that encode for proteins critical to the proper handling of electrons. The process of regulating the flow of electrons is known as redox control, and it is essential to the generation and regulation of energy in living systems. Thus, mitochondrial diseases are diseases of redox control. These diseases commonly result in severe neurological impairment and death at an early age. At present, there are no FDA- or EMA-approved treatments.
Through the reverse-engineering of mitochondrial diseases, BioElectron has been able to identify a number of initial drug targets, which has led to the development of drug candidates aimed at treating children with mitochondrial diseases. These drugs are in active clinical development. Our current lead drug, EPI-743, uniquely targets 15-lipoxygenase—a key enzyme involved in the regulation of oxidative stress, inflammation and programmed cell death (also known as ferroptosis), biological processes that are significant in the pathology of mitochondrial and other diseases.
We also possess a rich pipeline of other first-in-class targets, novel drug candidates, and paired diagnostics for a wide array of conditions; e.g. Parkinson’s disease, ALS, diabetes, autism and cancer. These conditions share a common biochemical basis—defects in electron-based (redox) cellular communication systems.
Biosceptre is a UK headquartered biotech developing next-generation cancer therapeutics utilising its proprietary target, nfP2X7. Biosceptre has an experienced team of scientists and executives based in state of the art facilities at the Babraham Research Campus, Cambridge UK and at Sydney Australia.
Biosceptre has multiple clinical programs designed to exploit nfP2X7 via a range of modalities including systemic antibodies, vaccines and topical therapeutics. A’s comprehensive global IP portfolio covers broadly both the target itself and multiple drug modalities, as well as multiple candidates designed to exploit nfP2X7.
Boston Pharmaceuticals acquires and transforms innovative molecules into differentiated medicines that improve patients’ lives. We have rapidly built a portfolio of high-value candidates across multiple therapeutic areas and are actively seeking additional programs for our diverse pipeline.
Caelus Health is an Amsterdam-based biotech company developing an entirely new class of Microbiome Therapeutics for the reduction of insulin resistance and prevention of Type 2 Diabetes (T2DM) in people with metabolic syndrome.
The company is dedicated to the commercialisation of functional food and pharmabiotic products for the prevention and early treatment of cardio metabolic diseases – based on the strong correlation between the intestinal microbiome and health.
Caelus Health builds on the experience of leading scientists in this field and is one of the very few companies that can effectively capture the value of Microbiome Therapeutics through their solid preclinical and early-stage clinical development approaches.
Cantargia specialises in antibody-based cancer treatment. CAN04, the company's patented antibody treatment, has a dual mechanism of action. CAN04 fights cancer by activating the immune system and blocking signals that lead to tumour growth. Treatment with CAN04 has the potential to become an important part of modern immuno-oncology.
Potential for several cancer diseases Cantargia is developing antibody-based treatments specifically targeting the molecule IL1RAP with a potential to treat a number of different cancers. The lead candidate, CAN04, is initially focused on non-small cell lung cancer (NSCLC) and pancreatic cancer and clinical trials started in 2017. The aim is to develop a new drug with the potential to become an important part of future cancer treatment.
Our product candidate CAN04 CAN04 is designed to block the cancer cell's signalling via the interleukin-1 system. Thereby counteracting the tumour inflammation that facilitates growth and protection of the tumour. CAN04 is also designed to stimulate the body's immune system to eliminate cancer cells directly.
Project CANxx Cantargia has started development of a new antibody against IL1RAP which will also be subject for patent protection. The new antibody is being designed for treatment of autoimmune and inflammatory diseases, with the aim to have a product candidate selected during 2019.
Background Cantargia AB was founded in 2009/2010 based on a discovery made by Professor Thoas Fioretos and Dr Marcus Järås at Lund University. Their research showed that leukaemic stem cells express a protein, IL1RAP, on the cell surface which is not expressed to the same extent on normal stem cells. Cantargia's research has since then shown that IL1RAP is also expressed in a range of solid tumour cancers.
IL1RAP is important for the cancer cells' ability to create a favourable environment for proliferation and expansion and antibodies targeting IL1RAP could potentially be used to treat several different forms of cancer, but also autoimmune and inflammatory diseases.
The CLINUVEL story starts in 1987 when university researchers launched an idea of synthesising human hormones to protect the skin. During this period, little was known about the properties of alpha-MSH (melanocyte stimulating hormone), although the scientists had discovered the biomimicry which these hormones could evoke (providing a golden glow without sun exposure). A basis was laid, but the majority of the research & development work was ahead to actually build a relevant product and successful company around this beginning scientific idea.
The CLINUVEL team in Australia obtained the rights to the technologies and established a company around alpha-MSH, its derivatives and knowledge. With an unabating focus and unusual willpower the CLINUVEL teams charged ahead and developed innovative technology which would release the hormonal analogue in picograms (10¯¹² grams) per day in a controlled fashion. With the world’s first dissolvable implant releasing a novel hormone to mimic the effects of the sun on human skin but without incurring the photo damage, our teams worked for two decades to test the technology - SCENESSE® - in more than 1,400 patients worldwide through 4,500 doses. Innovation came with rigid testing.
In 2014, the European Medicines Agency and the European Commission approved SCENESSE® as the world’s first photo protective drug for market authorisation to be distributed to European patients treated by specialist hospitals, dermatologists and other specialists. What had once been thought of as science fiction had become reality in October 2014, when SCENESSE® became the first systemic drug providing protection to the entire skin surface without exposure to light and UV. Currently, the Food and Drug Administration is reviewing the innovative pharmaceutical product for release in the United States. At CLINUVEL we focussed and specialised for two decades on extreme disorders which were provoked by environmental conditions, such as erythropoietic proto- and congenital porphyria [EPP, CEP], Solar Urticaria and other light-induced diseases. Worldwide the erythropoietic protoporphyria patients are forced to live an indoors existence deprived of any light source.
Cue Biopharma is committed to bringing selective immune modulation to patients through our Cue Biologics platform. Our talented scientists are led by an experienced management team and supported by leading scientific and clinical advisors with deep expertise in the design and clinical development of protein biologics to treat cancer and autoimmune diseases. Together, we are developing novel, targeted therapies aimed at overcoming many of the challenges facing prevailing immunotherapeutics. We are headquartered in Kendall Square, Cambridge, MA.
We are a global biotechnology company focused on further improving and leveraging the patented and proprietary C1 expression system to help bring biologic vaccines and drugs to market faster, in greater volumes, at lower cost, and with new properties to drug developers and manufacturers to improve access and cost to patients and the healthcare system – but most importantly to save lives.
Founded in 2015, EUSA Pharma is a privately-held, profitable, global oncology and rare disease biopharmaceutical company with established commercial operations in the EU and US. We have deep expertise in asset acquisition, regulatory approvals, reimbursement and the successful launch of oncology and rare disease products worldwide. EUSA has several FDA and/or EMA approved orphan oncology and rare disease assets in launch phase, including QARZIBA®, SYLVANT® and FOTIVDA®, with further development of these assets underway in additional niche indications with high unmet need.
Exogenus Therapeutics (Exo-T) is a biotechnology company dedicated to pre-clinical and clinical development of advanced therapies for skin lesions. Exo-T envisage becoming a company of reference for the use of exosomes as a treatment tool for wound healing. The company is presently developing its first product, Exo-Wound, for the treatment of chronic wounds, which affect millions of people worldwide.
F-star is a leader in the discovery and development of novel bispecific antibodiesF-star is a biopharmaceutical company focused on developing immuno-oncology bispecific antibody therapeutics.We are poised to dominate the bispecific antibody space in immuno-oncology through the application of our highly efficient Modular Antibody Technology™ platform.Our powerful platform enables the discovery of novel bispecific antibodies, which are selected for their potential to transform the treatment of cancer. The strength of the technology and programmes has been leveraged through partnerships with leading biopharmaceutical companies including: AbbVie, Bristol-Myers Squibb, Merck KGaA and Denali Therapeutics.We have built a comprehensive IP estate around our technology and product pipeline, with over 50 patent applications filed and over 25 granted patents.F-star’s management team has a well-established track record in building successful biotech companies, and developing biologics. The team is advised by a world-leading scientific advisory board and a highly experienced board of directors.F-star currently employs over 80 people at its research site in Cambridge, UK.
GeNeuro is a clinical stage pharmaceutical company developing a new approach to the treatment of autoimmune diseases, including multiple sclerosis (MS) and Type 1 Diabetes (T1D) associated with pathogenic proteins expressed by human endogenous retroviruses (HERV), viral genes that account for 8% of human DNA. This new approach is the result of 25 years of research on endogenous retroviruses, including 15 within Institut Mérieux and INSERM, before the creation of GeNeuro in 2006. This research has allowed us to discover and understand the action of a factor potentially causative of multiple sclerosis, the pathogenic MSRV protein, which is a member of the human endogenous retrovirus-W family (HERV-W). The presence of pathogenic HERV-W in the brains of patients may be an important cause of the inflammatory and neurodegenerative phenomena characterizing this disease.
GeNeuro has developed GNbAC1, a humanized monoclonal antibody, currently in Phase IIb clinical development in multiple sclerosis with the support of Servier, the context of a 362 M€ partnership signed in 2014. By neutralizing the pathogenic HERV-W protein rather than targeting the patient's immune system, GNbAC1 could prove to be both safe and effective, and potentially able to slow or even halt the progression of the disease in all its forms. GeNeuro develops its platform against other autoimmune diseases, such as type 1 diabetes for which a 60-patient Phase lla with GNbAC1 was launched in April 2017, and chronic inflammatory demyelinating polyneuropathy for which a proof-of-concept trial is planned to be launched by end of 2017. To capture the full therapeutic potential of its approach against pathogenic HERV proteins, GeNeuro is developing new therapeutics, currently at preclinical stage, against other pathologies such as inflammatory psychosis, as well as against amyotrophic lateral sclerosis for which GeNeuro has signed a research partnership with the NIH.
GeNeuro SA is a member of the Swiss Biotech Association, a member of the BioAlps community and has the CTI (Commission for Technology and Innovation) start-up label. GeNeuro Innovation SAS is member of the French Lyon Biopole.
Millions of people all over the world suffer from diseases, for which there is no known treatment. At the same time, thousands of skilled scientists are working on early research projects, which might one day provide novel therapies for the people in need.
Herantis Pharma Plc is an innovative drug development company focused on regenerative medicine for breakthrough in unmet clinical needs. Our first-in-class assets are based on globally leading scientific research in their fields: CDNF for disease modification in neurodegenerative diseases, primarily Parkinson’s and ALS; and Lymfactin® for breast cancer associated lymphedema, with potential also in other lymphedemas.
Herantis’ shares are listed on NASDAQ OMX Helsinki First North Finland.
IGEM Therapeutics is a UK Immuno-Oncology company developing novel IgE antibodies to treat cancer. IgE has evolved to kill tissue-dwelling multicellular parasites endowing it with several key features that make it ideal for the treatment of solid tumours which also mostly reside in tissue. The epsilon constant region of IgE binds very tightly to its cognate receptor (FcεRI) on the surface of immune effector cells including macrophages, monocytes, basophils and eosinophils. This interaction is up to 10,000 fold greater than the gamma chain of IgG has for its equivalent receptor and this results in the majority of IgE molecules being permanently attached to the surface of immune effector cells. The latter are therefore primed and ready to destroy cells expressing the antigen recognised by the IgE. As a result, IgE is able to permeate tissues more effectively than IgG and stimulate significantly greater levels of both ADCP (antibody-dependent cell-mediated phagocytosis) and ADCC (antibody-dependent cell-mediated cytotoxicity), the two main mechanisms by which immune effector cells can kill tumour cells. IgE also has a significantly longer tissue half life than IgG (2 weeks versus 2 – 3 days) which also suits it for a role in the destruction of solid tumours.
The company’s lead programme targets the folate receptor alpha (FR alpha) and an anti-FR alpha IgE antibody is currently in a phase 1/2a trial to treat ovarian cancer. This is the world’s first IgE therapeutic to enter the clinic.
IGEM is also developing a novel antibody platform technology based on protein and glyco-engineering of the epsilon constant region.
ILTOO Pharma is a clinical-stage biotechnology company dedicated to the development of biotherapies that have the ability to balance the immune system and revolutionize the treatment of autoimmune and inflammatory disorders (ADs). Based on a deep expertise in translational research and clinical immunology, ILTOO Pharma is pioneering the field of regulatory T cells (Tregs)-mediated immunotherapies.
ILTOO Pharma lead product, ILT-101, is the world most advanced IL-2-based therapies. ILTOO’s vision is that, along with corticosteroids and anti-TNFs antibodies, IL2-mediated immunotherapy will become the next-generation standard of care for treating ADs. Systemic lupus erythematosus (SLE) and recently diagnosed type-1 diabetes (T1D) have been selected as top priority indications. By targeting an immunological imbalance which is the common root cause of ADs, ILT-101 has the potential to bring an enhanced therapeutic benefit to a wide spectrum of patients affected by ADs.
Immunicum is developing novel immuno-oncology therapies against a range of solid tumors. The approach is based on allogeneic dendritic cells that are designed to stimulate a personalized anti-tumor immune response in each patient. The Company’s lead compound, ilixadencel is currently being evaluated in clinical trials for the treatment of kidney cancer, liver cancer and gastrointestinal stromal tumors. Ilixadencel combines the best aspects of two approaches: a cell-based, cost-effective and off-the-shelf immune enhancer that when injected intratumorally is capable of triggering a highly specific and potentially long-lasting immune reaction against tumor cells throughout the body.
Immunomic Therapeutics, Inc. (ITI) is a privately-held clinical stage biotechnology company pioneering the study of the LAMP-based nucleic acid immunotherapy platforms. These investigational technologies have the potential to alter how we use immunotherapy for cancer, allergies and animal health. On the heels of two landmark deals in 2015, including an exclusive worldwide license with Astellas Pharma Inc. to explore the use of LAMP-Vax™ for use in the prevention and treatment of allergic diseases which resulted in over $315M in licensing revenue that year, the company has now focused on the application of LAMP technology in oncology.
INOTREM SA is a biopharmaceutical company discovering and developing first-in-class immunotherapies for the treatment of inflammatory diseases. The Company is developing a new concept of immunomodulation targeting the amplification loops of the innate immune response with an initial focus on septic shock. With a high mortality rate, a growing incidence and a lack of specific mechanistically targeted treatment, severe sepsis and septic shock is a major public health problem in urgent need of a solution.
The INOTREM scientists and co-founders are international leaders in TREM-1 biology (Triggering Receptor Expressed on Myeloid cells-1) and authors of numerous studies demonstrating the role of TREM-1 in severe sepsis as well as myocardial infarction.
InterAx is a Swiss Biotech company spinoff from the ETH Zürich and Paul Scherrer Institute.
InterAx assists drug candidate design and selection with its unique and novel systems biology platform. This technology allows for the integration of both, experimental and computational pharmacology, and is able to predict in vivo effects of drug candidates by analyzing complex experimental in vitro data sets. Currently, the InterAx technology is applicable to all drug discovery programs on G protein-coupled receptors (GPCRs).
Karyopharm Therapeutics Inc. is a clinical-stage pharmaceutical company focused on discovery and development and subsequent commercialization of novel first-in-class drugs directed against nuclear transport and related targets for the treatment of cancer and other major diseases.
Our scientific expertise is focused on understanding the regulation of intracellular communication between the nucleus and the cytoplasm. We have discovered and are developing novel, small molecule Selective Inhibitor of Nuclear Export, or SINE, compounds that inhibit the nuclear export protein XPO1. These SINE compounds represent a new class of drug candidates with a novel mechanism of action that have the potential to treat a variety of diseases in areas of unmet medical need. Our SINE compounds were the first oral XPO1 inhibitors in clinical development.
Our lead drug candidate, selinexor (KPT-330), is an XPO1 inhibitor being evaluated in multiple late stage clinical trials in patients with relapsed and/or refractory hematological and solid tumor malignancies.
LIfT BioSciences is a socially-minded Biotech start-up developing The World's First Cell Bank of Cancer Killing Granulocytes (a type of white blood cell). The Cell Bank will enable us to provide a range of potentially life-saving immuno-oncology cell therapies for different solid tumour types. Our innate immunity platform is known as Neutrophil only Leukocyte Infusion Therapy (N-LIfT), a first-in-class patented cell therapy. N-LIfT is produced ex-vivo and benefits from being more scalable with potentially better and more consistent efficacy and safety than other forms of leukocyte infusion.
LIfT BioSciences Ltd was set-up with Prof Zhen Cui of Wake Forest University, a leading pioneer in LIFT, following his discovery of a cancer resistant (SR/CR) mouse that proved to have transferable innate immunity.
The first targeted indication is pancreatic cancer (pancreatic ductal adenocarcinoma – PDAC), one of the types of cancer with the highest unmet medical need. CRUK report that just 3% of Patients Diagnosed with PDAC survive 5 years. PDAC is classified as an orphan disease by European Medicines Agency (EMA) which will facilitate our market access. The EMA has classified N-LIfT as an Advanced Therapeutic Medicinal Product (ATMP), which sets us up for accelerated approval (early access scheme) and enhanced proprietary protection (market and data exclusivity), subject to trial results.
We are currently completing pre-clinical work before running our first in-human clinical trial. The aim is to demonstrate remission in high unmet need solid tumours by 2021, including Pancreatic Cancer.
Due to the sensitivity of our work and the IP required to successfully bring this therapy to market we are unable to disclose more at present. If you would like to find out more, or if you would be interested in investing please Contact Us.
Medherant is developing the next generation of patches for local and transdermal delivery of drugs. TEPI Patch. Medherant was founded by Professor David Haddleton and the University of Warwick to develop and commercialise novel technologies for delivery of drugs via the skin using their world-leading expertise in bioadhesives and polymer chemistry. The Company is based on the University of Warwick Science Park in Coventry (UK). Medherant has received investment from Mercia Fund Management and others. Delivery of drugs using patches that are applied to the skin provides better control of the dose than with gels, ointments and creams. However, the currently available technologies limit the types of drugs that can be used and the quantities that can be loaded into the patch. Medherant’s TEPI Patch® is formulated with a novel polymer adhesive which has been exclusively licensed from Bostik. The drug to be delivered is mixed with the adhesive to form a thin, flexible, single layer patch.
One of the key advantages of the TEPI Patch® technology is that a greater quantity of drug can be blended with the adhesive. This enables lower potency drugs to be formulated as a patch and provides the opportunity to increase the dose of drugs already administered via a patch or reduce patch size. The TEPI Patch® also provides a better experience for the user as it does not leave a residue around the patch – referred to as ‘cold flow’ – and has excellent adhesion whilst still being easy and painless to remove. Medherant is developing its own TEPI Patch® products and working with third parties to assess the suitability of the technology for their drugs. The Company expects to earn revenues from licensing products that it has developed to pharmaceutical companies and through collaborative development projects leading to potential technology licences.
Memo Therapeutics AG (MEMO) is an innovator in the field of antibody discovery and immune repertoire analysis. Its MemoMABTM platform creates a recombinant in vitro copy of an individual’s B cell / antibody repertoire, which is then banked as a library. The resulting unique, large and relevant antibody libraries represent the individual’s immune repertoire and are expected to contain an unprecedented number of relevant and rare antibodies. This leads to entirely new possibilities in immune repertoire analysis and antibody discovery. The business strategy of MEMO is the discovery of therapeutic antibody candidates and target discovery for antibody and vaccine development. MemoMABTM is deployed in proprietary antibody lead discovery programs and is made available in collaborations.
Metys Pharmaceuticals is developing dimiracetam for the prevention of chemotherapy-induced painful peripheral neuropathy. In the US alone, in a single year, more than 400'000 patients suffer from the neuropathy caused by their life-saving cancer treatment. No drug has been approved to prevent or treat this condition. Dimiracetam is an orally active, small molecule with more than 200 patients' safety and tolerability data; dimiracetam is highly effective in preventing and treating chemotherapy-induced neuropathy in rodents. Metys Pharmaceuticals is preparing the first dedicated efficacy study of dimiracetam in this indication.
MGC Pharmaceuticals Ltd (ASX: MXC) is a European-based specialist Medical Cannabis company built on a mission to be an international pioneer in Phytocannabinoid-based medicine within the biopharmaceutical industry.
Heralding countless years of practical, scientific and business experience, MGC Pharma’s founders are all prominent leaders in the Medical Cannabis industry.
MGC Pharma’s principal business goal is to produce and supply high quality Cannabinoid based pharmaceutical products for the emergent medical markets in Europe, North America and Australasia.
Our vaccines are designed to induce protection against early transmission and infection, focusing both on the mucosal immune response as a first-line defense and the systemic humoral (blood) immune response, which, for some pathogens, may be essential for the development of an effective prophylactic vaccine. Our unique approach has resulted in the development of a rich pipeline of vaccine candidates for HIV-1/AIDS, intra nasal Influenza, Malaria, Chikungunya and the Respiratory Syncytial Virus (RSV) vaccine. Our delivery platform is being validated through partnership with leading pharmaceutical or research organisations, including Sanofi, PATH-MVI and the Bill and Melinda Gates Foundation. Mymetics Corporation (OTCQB: MYMX) is a Swiss based biotechnology company, with a Research Lab in the Netherlands. The company is registered in the US and trades on the OTCQB.
Nanobiotix is a late stage clinical company pioneering nanomedicine for more than a decade. We intend to significantly change the outcomes for cancer patients following a different path than other Pharma or Biotech companies: a new way to treat patients thanks to nanophysics at the heart of the cell.
Nanobiotix is a spin-off from the State University of New York (SUNY), Buffalo and was incorporated in 2003. Nanobiotix is listed on the regulated market of Euronext Paris on 29 October 2012 (ISIN: FR0011341205, Euronext ticker: NANO, Bloomberg: NANO: FP).
Nanobiotix operates worldwide from the headquarters based in Paris, France and affiliate office in Cambridge, MA, USA. Nanobiotix has partnered with PharmaEngine for clinical development and commercialization of NBTXR3 in Asia.
The company’s first technology, NanoXray, is based on proprietary technologies and patents. The goal of our products is to help millions of patients receiving radiotherapy by magnifying the effect of radiotherapy within tumor cells, without increasing the dose to surrounding healthy tissues.
We develop first-in-class products with the aim to provide a maximum benefit with a minimum change in the medical practice in order to limit the hurdle of healthcare cost.
The most advanced product, NBTXR3, is in registration clinical phase and the Company has filed in August 2016 for market approval (CE Marking) in Europe.
NovaGo Therapeutics is a biotech start-up company dedicated to the development of human antibody therapeutics targeting cerebral stroke and spinal cord injury to stimulate nerve repair and regeneration. A strategic partnership with Neurimmune provides access to a unique class of human-derived antibodies with exceptional therapeutic properties generated through their Reverse Translational Medicine™ (RTM™) technology platform.
The founding and management team has a proven track record in research and drug development. Existing collaborations and networks with partners in industry, academia, and the medical community leverage the advancement of our programs.
Novaremed AG is a clinical-stage Swiss biopharmaceutical company, HQ in Basel, Switzerland, with a subsidiary in Israel. Novaremed is developing an orally active, first-in-class, small molecule (NRD.E1), with a novel mechanism of action, to treat Diabetic Neuropathic Pain.
Oryzon is a public clinical stage biopharmaceutical company and the European leader in the development of epigenetics-based therapeutics. From its founding in 2000 through 2008, the company focused its efforts in growing a genomics diagnostics business model, providing genomics services to the pharmaceutical industry in Europe. In 2008, with the acquisition of Crystax Pharmaceuticals, we started our drug discovery programs in oncology and neurodegenerative diseases. Our business model is to develop our proprietary drug candidates through clinical phase II, at which point it is decided on a case-by-case basis to either keep the development in-house or to partner or outlicense the compound for late stage development and commercialization. Oryzon is listed on the Spanish Stock Exchange since December 2015 (ORY, ISIN Code: ES0167733015). In the period 2015-2016, the company raised €32M, with additional €18.2M raised from blue chip investors in the US and Europe in March 2017.
With two compounds in clinical trials, ORY-1001, a highly potent and selective LSD1 inhibitor that has been granted orphan-drug status by EMA, in Phase I/IIA in oncology, and ORY-2001, a dual LSD1/MAO-B inhibitor for the treatment of multiple sclerosis, Alzheimer’s disease and other neurodegenerative diseases, in Phase IIA, as well as another compound in preclinical development, ORY-3001, a selective LSD1 inhibitor for the treatment of non-oncological diseases, and additional programs in other cancer indications, the company has a broad and growing portfolio. From 2014 to 2017 the company had a collaboration with Roche relating to our lead oncology program and received +$23M. This asset is now being developed by Oryzon. The company has also obtained competitive US and European grants in the amount of €8M to support the development of ORY-2001 since the start of our CNS research.
The company has a seasoned executive management with vast experience in the industry.
OSE Immunotherapeutics (Nantes – ISIN : FR0012127173 ; Mnemo : OSE) was created in May 2016 through the merger of OSE Pharma, an immuno-oncology company developing specific immunotherapy activating T lymphocytes, and Effimune, a biotechnology company specializing in immune regulation with clinical applications in autoimmunity, transplantation and immuno-oncology.OSE Immunotherapeutics is a biotechnology company dedicated to the development of innovative immunotherapies which act on effector and suppressor cells to stimulate or inhibit the body’s immune response, and to restore immune disorders in the fields of immuno-oncology, autoimmune diseases and transplantation.These new generation products are optimized to better target key receptors of the immune response’s activation or regulation, thus allowing for longer therapeutic effects.OSE Immunotherapeutics is specialized in the immune system regulation and activation technologies. The company relies upon its international and complementary team of experts involved in the research and optimisation of drug candidates, pharmaceutical development and drug registration.
PDC*line Pharma is a French-Belgium clinical-stage biotech company that develops a new class of active immunotherapies for cancer based on an allogeneic cell line of Plasmacytoid Dendritic cells (PDC*line) loaded with cancer antigens. PDC*mel, our first drug candidate is currently in phase 1 clinical trials for melanoma. PDC*lung is in preclinical development for lung cancer. Our approach can be applied to virtually any type of cancer and any patient population, and combined with differents cancer treatments.
Pharmaleads aims to provide patients suffering from severe chronic and acute pain with improved pain relief without the side effects associated with other classes of analgesics. Based on years of experience in the design of highly potent and specific inhibitors of enkephalinases, Pharmaleads has developed a new class of analgesics called DENKIs (Dual Enkephalinases inhibitors). These small molecules are able to provide patients with local and sustainable pain relief.
Pharmaleads’ DENKIs are first-in-class drugs with a novel mechanism of action tackling pain by using endogenous enkephalins, natural peptides that specifically bind to pain-related opioid receptors to naturally modulate pain without the side effects observed with exogenous opioid drugs that also bind to other opioids receptors, not involved in pain control, triggering multiple side effects. Pharmaleads believes its products can change the lives of the many patients who are in need of improved treatment options for their chronic and/or acute pain, and could offer healthcare providers with an improved pain management option that helps address the opioid epidemic.
Rejuvenate Biomed is a biomedical company researching the biology of aging and applying this knowledge to identify safe and well tolerated drugs that balance core biological processes delaying age-related functional decline.
Selvita is one of the largest drug discovery companies in Europe. The company has two primary focus areas: to serve the drug discovery market as a customer centric provider of high quality, integrated drug discovery services, and as a drug discovery company engaged in the research and development of breakthrough therapies in oncology.The company was established in 2007 and currently employs over 400 scientists, among which 30% are PhDs.Selvita is headquartered in Krakow, Poland, with a second research site in Poznan, Poland and foreign offices located in Cambridge, MA and San Francisco Bay Area, in the US, as well as in Cambridge, UK .Our scientists have extensive experience in life sciences, and we offer the following:Contract chemistry servicesBiology servicesIntegrated drug discovery projectsComparative studies of biosimilar medicinal products Selvita’s laboratories are GLP and GMP-certified.Selvita’s internal R&D department focuses on oncology.
The company’s most advanced R&D program is SEL24, a dual PIM/FLT3 kinase inhibitor, which has entered the clinic in March 2017, and was subsequently licensed to Menarini Group.The second most advanced program is SEL120, a first-in-class small molecule inhibitor of CDK8 with potential use in hematological malignancies, colorectal cancer and breast cancer is currently developed in partnership with The Leukemia and Lymphoma Society.Selvita Early Discovery programs include: Immunooncology platform, Epigenetic platform, program targeting metabolic abnormalities in cancer, as well as an early discovery stage programs in the area of protein kinases.The company has alliances and partnerships with more than fifty large and medium-sized pharmaceutical and biotechnology companies from USA and Europe, including R&D partnerships with Merck, H3 Biomedicine, Nodthera Therapeutics, as well as Menarini Group and The Leukemia and Lymphoma Society.Selvita is listed on the Warsaw Stock Exchange (WSE:SLV).
Sensorion is a biopharmaceutical company, formed in 2009, focused as a “pure player” on developing therapies for debilitating inner ear disorders. With our primary strength in the inner ear and neurosciences, we combine world-class scientific excellence and top-tier execution capabilities to deliver first-in-class therapeutics. Sensorion was initially founded by French and European academics, and has now diversified its core competencies by recruiting a network of partners and key opinion leaders. Our leadership has exceptional, solid experience in research, marketing and finance.
STALICLA is a mission-driven biotech, with a unique patient centric vision, that is poised to become a disruptive industry challenger and future global leader in personalized treatment options for patients with Autism Spectrum Disorder (ASD). At STALICLA, we have developed an innovative algorithm platform that uses robust sets of clinical signs and symptoms with big data analytics to identify subgroups of ASD patients. By identifying these subgroups, we aim to offer repurposed drugs that provide more effective, personalized treatment options. The company was founded in Geneva, Switzerland in May 2017 by today’s CEO Lynn Durham, a biotech entrepreneur with a lifelong involvement with the autism community. STALICLA has established a research partnership with the Greenwood Genetic Center, South Carolina, USA, a leading translational research center in genetics and neurodevelopmental disorders, including ASD.
TapImmune is developing immunotherapies for a variety of cancers designed to target both tumors and metastatic disease. The company’s next-generation technology has been engineered to overcome the deficiencies of earlier cancer vaccine approaches and has the potential to be a powerful standalone therapy or part of a leading combination regimen by complementing other approved or development-stage immunotherapeutics (i.e. checkpoint inhibitors). The company’s off-the-shelf vaccines boost patients’ immune systems to comprehensively stimulate both killer T-cells and helper T-cells to destroy cancer cells, and they are designed to work with 80% of the population.TapImmune is advancing two clinical stage T-cell vaccine candidates in multiple Phase II and Phase Ib/IIa clinical trials for treating ovarian and breast cancers, including programs in ovarian cancer that will benefit from FDA Fast Track and Orphan Disease Designation. The company is working in collaboration with industry and clinical leaders including Mayo Clinic, Memorial Sloan Kettering Cancer Center, and AstraZeneca.
Themis has developed a sophisticated vaccine platform and broad pipeline based on the advanced understanding of immune system mechanisms. Initially focused on preventing infectious diseases, the Company has demonstrated the potential of its versatile platform through the rapid progression into Phase 2 clinical development for a vaccine against Chikungunya, a debilitating disease with global outbreak potential. Funded to date by leading EU-based VCs, Themis has also gained prestigious non-dilutive funding for emerging infectious disease indications. The Company will apply its platform and manufacturing capabilities to diseases with high market potential both alone and for its partners.
ThromboGenics is a global biotechnology company delivering innovative treatments for diseases of the back of the eye, with a focus on diabetic eye disease. Our first product, JETREA® (ocriplasmin), has been approved in 54 countries worldwide.
The company is strongly committed to R&D on treatments for diabetes-related eye diseases such as diabetic retinopathy (DR) and diabetic macular edema (DME). We recently launched a Phase II clinical trial with THR-409 (ocriplasmin) in diabetic retinopathy.
ThromboGenics is headquartered in Leuven, Belgium, with offices in Iselin, NJ (US) and Dublin, Ireland. The company is listed on the NYSE Euronext Brussels exchange under the symbol THR.
Topas’ technology platform induces antigen-specific immune tolerance by utilizing the liver’s natural immunology capabilities. We target liver sinusoidal endothelial cells (LSECs), which generate tolerance against bloodborne antigens. Topas’ peptide-loaded nanoparticles mimic such bloodborne antigens and follow their natural processing in LSECs, including the generation of long-lasting antigen-specific regulatory T-cells (Tregs). This allows us to develop novel therapeutic solutions for autoimmune diseases, allergies and anti-drug antibodies.
VAXIMM is a privately held, clinical stage, Swiss/German biotech company developing oral T-cell immunotherapies for patients suffering from cancer. VAXIMM’s technology is based on first-in-class oral T-cell activators using modified attenuated bacteria that can be readily adapted to target a wide range of cancer-related antigens. The Company’s lead product candidate, oral VXM01, currently in clinical trials, activates killer T-cells targeting tumor vasculature and certain immune-suppressive cells and causes increased inflammation in solid tumors. VAXIMM completed a Phase I/II trial of VXM01 in advanced pancreatic cancer. Clinical trials are completed or ongoing in metastatic colorectal cancer and in recurrent glioblastoma (brain cancer).
The Company has several additional product candidates at various stages of preclinical development. These candidates can be developed as stand-alone therapies or in combination with other immunotherapies, including VXM01. Investors in our company include: BB Biotech Ventures, Merck Serono Ventures, Sunstone Capital and BioMed Partners. VAXIMM AG is headquartered in Basel, Switzerland with a wholly owned subsidiary, VAXIMM GmbH (Mannheim, Germany), from where the Company’s development activities are orchestrated, and a laboratory in Regensburg, Germany.